Document Detail

Effects of clozapine on CSF homovanillic acid in spasmodic torticollis.
MedLine Citation:
PMID:  7873132     Owner:  NLM     Status:  MEDLINE    
We studied the effect of the atypical neuroleptic clozapine (CLO) on homovanillic acid (HVA) in cerebrospinal fluid (CSF) in five patients with spasmocid torticollis. Lumbar puncture was performed before and on the seventh day of CLO treatment. Although an HVA elevation was to be expected because of the antidopaminergic action of CLO, statistical analysis failed to reveal any significant increase of HVA under CLO treatment. Thus significance of CSF HVA may be less important for the description of antidopaminergic action of neuroleptics than previously assumed.
A Thiel; D Dressler; A Reimer; E Rüther
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neural transmission. General section     Volume:  97     ISSN:  -     ISO Abbreviation:  J. Neural Transm. Gen. Sect.     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-03     Completed Date:  1995-04-03     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9002201     Medline TA:  J Neural Transm Gen Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
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MeSH Terms
Clozapine / blood,  pharmacology*
Homovanillic Acid / cerebrospinal fluid*
Middle Aged
Torticollis / cerebrospinal fluid*
Reg. No./Substance:
J60AR2IKIC/Clozapine; X77S6GMS36/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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