| Effects of clozapine on CSF homovanillic acid in spasmodic torticollis. | |
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MedLine Citation:
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PMID: 7873132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of the atypical neuroleptic clozapine (CLO) on homovanillic acid (HVA) in cerebrospinal fluid (CSF) in five patients with spasmocid torticollis. Lumbar puncture was performed before and on the seventh day of CLO treatment. Although an HVA elevation was to be expected because of the antidopaminergic action of CLO, statistical analysis failed to reveal any significant increase of HVA under CLO treatment. Thus significance of CSF HVA may be less important for the description of antidopaminergic action of neuroleptics than previously assumed. |
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Authors:
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A Thiel; D Dressler; A Reimer; E Rüther |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of neural transmission. General section Volume: 97 ISSN: 0300-9564 ISO Abbreviation: J. Neural Transm. Gen. Sect. Publication Date: 1994 |
Date Detail:
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Created Date: 1995-04-03 Completed Date: 1995-04-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9002201 Medline TA: J Neural Transm Gen Sect Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 245-51 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Georg-August-University, Göttingen, Federal Republic of Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clozapine / blood, pharmacology* Female Homovanillic Acid / cerebrospinal fluid* Humans Male Middle Aged Torticollis / cerebrospinal fluid* |
| Chemical | |
Reg. No./Substance:
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306-08-1/Homovanillic Acid; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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