| Effects of clonidine and yohimbine on a C-fibre-evoked blood pressure reflex in the rat. | |
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MedLine Citation:
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PMID: 3179615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The involvement of alpha 2-adrenoceptors in a capsaicin-induced depressor reflex in the rat has been investigated. 2. The reflex fall in blood pressure following an intra-arterial injection of capsaicin was partially blocked by an intrathecal infusion of clonidine (1 microgram) at the spinal cord level L4-L5, an effect which was abolished by the prior intrathecal infusion of yohimbine (5 micrograms). 3. Clonidine (1 microgram) given intracisternally blocked the depressor reflex almost completely; however, it also produced a gradual, prolonged fall in mean carotid pressure. 4. Yohimbine (20 micrograms) given intracisternally did not change mean blood pressure but had a dual effect on the depressor reflex in response to the capsaicin injection: a short period of enhanced reflex response was followed by a long lasting inhibition of the response. 5. It was concluded that alpha 2-adrenoceptors in the spinal cord inhibit the capsaicin-evoked depressor reflex and that pre- and postsynaptic alpha 2-adrenoceptors in the brain stem modulate this reflex. |
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Authors:
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J Donnerer; Z Yan; F Lembeck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 94 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-12-21 Completed Date: 1988-12-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 848-52 Citation Subset: IM |
Affiliation:
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Department of Experimental and Clinical Pharmacology, University of Graz, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Capsaicin / antagonists & inhibitors, pharmacology* Cisterna Magna Clonidine / administration & dosage, pharmacology* Female Injections Injections, Spinal Male Nerve Fibers / drug effects* Rats Rats, Inbred Strains Reflex / drug effects Yohimbine / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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146-48-5/Yohimbine; 404-86-4/Capsaicin; 4205-90-7/Clonidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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