| Effects of clonidine and isoflurane on the myocardial contractility behavior of isolated rat hearts. | |
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MedLine Citation:
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PMID: 20150043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isoflurane is chosen as an anesthesia drug for cardiac surgeries, and its effectiveness and safety have been proved in countless clinical studies. Clonidine, a central alpha-agonist, has recently been added to isoflurane to attenuate sympathetic hyperactivity by acting directly on its site of origin in the central nervous system. The ability of alpha2-adrenoceptor agonists to inhibit central sympathetic outflow may benefit patients at risk of myocardial damage by improving myocardial oxygen demand and the supply ratio and contributing to hemodynamic stability. We investigated the effects of clonidine and isoflurane, alone and in combination, on the myocardial contractility of isolated rat hearts and found that use of clonidine plus isoflurane decreased the systolic pressure somewhat, but use of the drugs separately did not exhibit this effect. Clonidine plus isoflurane did not affect +(dP/dt)max, but it did decrease -(dP/dt)max significantly compared with the use of isoflurane alone. These results indicate that clonidine and isoflurane have the capacity to interact with each other. The capacity of clonidine to decrease isoflurane's inotropic effect could theoretically contribute to improving the myocardial oxygen demand and the supply ratio, decreasing surgical stress, and benefiting patients at risk of myocardial damage. |
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Authors:
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João Bosco Dupin; Alfredo Inácio Fiorelli; João Henrique Dupin; Ana Elisa Dupin; Isabela Maria Dupin; Otoni M Gomes |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The heart surgery forum Volume: 13 ISSN: 1522-6662 ISO Abbreviation: Heart Surg Forum Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-12 Completed Date: 2010-05-07 Revised Date: 2011-08-05 |
Medline Journal Info:
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Nlm Unique ID: 100891112 Medline TA: Heart Surg Forum Country: United States |
Other Details:
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Languages: eng Pagination: E57-9 Citation Subset: IM |
Affiliation:
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São Francisco de Assis Truth is Jesus Cardiovascular Foundation, Belo Horizonte, Brazil. dupinjb@terra.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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administration & dosage Animals Antineoplastic Combined Chemotherapy Protocols Clonidine / administration & dosage* Dose-Response Relationship, Drug Isoflurane / administration & dosage* Male Myocardial Contraction / drug effects*, physiology* Rats Rats, Wistar Ventricular Function, Left / drug effects*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 26675-46-7/Isoflurane; 4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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