Document Detail

Effects of clonidine and isoflurane on the myocardial contractility behavior of isolated rat hearts.
MedLine Citation:
PMID:  20150043     Owner:  NLM     Status:  MEDLINE    
Isoflurane is chosen as an anesthesia drug for cardiac surgeries, and its effectiveness and safety have been proved in countless clinical studies. Clonidine, a central alpha-agonist, has recently been added to isoflurane to attenuate sympathetic hyperactivity by acting directly on its site of origin in the central nervous system. The ability of alpha2-adrenoceptor agonists to inhibit central sympathetic outflow may benefit patients at risk of myocardial damage by improving myocardial oxygen demand and the supply ratio and contributing to hemodynamic stability. We investigated the effects of clonidine and isoflurane, alone and in combination, on the myocardial contractility of isolated rat hearts and found that use of clonidine plus isoflurane decreased the systolic pressure somewhat, but use of the drugs separately did not exhibit this effect. Clonidine plus isoflurane did not affect +(dP/dt)max, but it did decrease -(dP/dt)max significantly compared with the use of isoflurane alone. These results indicate that clonidine and isoflurane have the capacity to interact with each other. The capacity of clonidine to decrease isoflurane's inotropic effect could theoretically contribute to improving the myocardial oxygen demand and the supply ratio, decreasing surgical stress, and benefiting patients at risk of myocardial damage.
João Bosco Dupin; Alfredo Inácio Fiorelli; João Henrique Dupin; Ana Elisa Dupin; Isabela Maria Dupin; Otoni M Gomes
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The heart surgery forum     Volume:  13     ISSN:  1522-6662     ISO Abbreviation:  Heart Surg Forum     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-12     Completed Date:  2010-05-07     Revised Date:  2011-08-05    
Medline Journal Info:
Nlm Unique ID:  100891112     Medline TA:  Heart Surg Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E57-9     Citation Subset:  IM    
São Francisco de Assis Truth is Jesus Cardiovascular Foundation, Belo Horizonte, Brazil.
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MeSH Terms
Analgesics / administration & dosage
Antineoplastic Combined Chemotherapy Protocols
Clonidine / administration & dosage*
Dose-Response Relationship, Drug
Isoflurane / administration & dosage*
Myocardial Contraction / drug effects*,  physiology*
Rats, Wistar
Ventricular Function, Left / drug effects*,  physiology*
Reg. No./Substance:
0/Analgesics; 26675-46-7/Isoflurane; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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