| Effects of clonidine on baroreceptor function in anesthetized dogs. | |
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MedLine Citation:
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PMID: 1122937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of clonidine (15-30 mug/kg i.v.) on carotid sinus and other baroreceptors were investigated in anesthetized dogs. In 14 control dogs, right carotid sinus pressure was controlled by retrograde perfusion through the common carotid artery at constant flow with femoral arterial blood. Graded reductions in heart rate and blood pressure induced by graded increases in carotid sinus pressure were prevented, whereas reflex bradycardias associated with norepinephrine pressor activity were potentiated by clonidine. Norepinephrine-induced bradycardia, although reduced, still persisted after chronic bilateral sinusectomy and these responses were also potentiated by clonidine. In contrast, clonidine did not potentiate reflex bradycardia in dogs 20 days after aortic stripping. In intact dogs, clonidine inhibited the response to bilateral carotid artery occlusion and to carotid sinus nerve stimulation. These studies suggest that clonidine can inhibit carotid sinus baroreceptor function and simultaneously potentiate other, presumably aortic, baroreceptor activity. |
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Authors:
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M J Antonaccio; R D Robson; R Burrell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 30 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-06-29 Completed Date: 1975-06-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 6-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Aorta / physiology Carotid Arteries / physiology Carotid Sinus / drug effects, physiology Clonidine / pharmacology* Denervation Depression, Chemical Dogs Dose-Response Relationship, Drug Drug Synergism Electric Stimulation Female Heart Rate / drug effects Male Norepinephrine / pharmacology Perfusion Pressoreceptors / drug effects* |
| Chemical | |
Reg. No./Substance:
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4205-90-7/Clonidine; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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