| Effects of cisapride on postcibal jejunal motor activity. | |
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MedLine Citation:
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PMID: 2766908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the jejunum of fasting humans, cisapride induces a phase 2-like, highly propagative motor pattern. This study investigated cisapride's effects on the fed pattern of the jejunum. Starting 5 min after a phase 3 of the migrating motor complex, 18 healthy men received 5 or 10 mg cisapride or placebo orally in random double-blind fashion and ingested meals containing 1000 and 4200 kJ, respectively. Jejunal pressures were recorded pneumohydraulically with five catheter orifices 10-30 cm aboard the ligament of Treitz. After the 4200-kJ meal, total number and number of propagated contractions as well as area under the curve increased significantly more than after 1000 kJ. Following the 1000-kJ but not the 4200-kJ meal, 10 mg cisapride increased total number of contractions, number of propagated contractions, mean amplitude, and area under curve significantly more than placebo. Fed-pattern duration increased with the meal's caloric content but was not influenced systematically by cisapride. In conclusion, cisapride stimulates jejunal motor activity and induces a propagative pattern after a 1000-kJ but not after a 4200-kJ meal, suggesting that it can produce no further stimulation when motor activity is near maximally enhanced already. |
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Authors:
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G Stacher; G Gaupmann; H Steinringer; C Schneider; G Stacher-Janotta; G Steiner-Mittelbach; T A Abatzi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 34 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1989-09-25 Completed Date: 1989-09-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1405-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cisapride Double-Blind Method Eating Fasting Gastrointestinal Motility / drug effects* Humans Jejunum / drug effects Male Muscle Contraction / drug effects Piperidines / pharmacology* Pressure Random Allocation Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 81098-60-4/Cisapride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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