Document Detail


Effects of cisapride on oesophageal transit of solids in patients with progressive systemic sclerosis.
MedLine Citation:
PMID:  11954884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.
Authors:
S J Wang; J L La; D Y Chen; Y H Chen; T Y Hsieh; W Y Lin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical rheumatology     Volume:  21     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-04-16     Completed Date:  2002-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  43-5     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan. sjwang@vhgtc.vghtc.gov.tw
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Cisapride / administration & dosage,  therapeutic use*
Cross-Over Studies
Double-Blind Method
Esophageal Motility Disorders / drug therapy*,  etiology*,  physiopathology,  radionuclide imaging
Esophagus / drug effects*,  physiopathology*,  radionuclide imaging
Female
Gastrointestinal Agents / adverse effects,  therapeutic use*
Humans
Male
Middle Aged
Scleroderma, Systemic / complications*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Gastrointestinal Agents; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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