Document Detail

Effects of cisapride on QTc interval in neonates.
MedLine Citation:
PMID:  9462199     Owner:  NLM     Status:  MEDLINE    
AIM: Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride. METHODS: QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996. RESULTS: Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestational age were lower. The prolongation of QTc interval above the arbitrary value of 0.450 (n = 7) was clinically asymptomatic and was significantly more common in the infants born with a gestational age < or = 33 weeks (n = 6). CONCLUSION: The findings indicate that cisapride accumulates in less mature neonates. Further pharmacokinetic studies are needed.
S Bernardini; D S Semama; F Huet; C Sgro; J B Gouyon
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  77     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-19     Completed Date:  1998-02-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F241-3     Citation Subset:  AIM; IM    
Centre Hospitalier Universitaire, Dijon, France.
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MeSH Terms
Electrocardiography / drug effects*
Gastroesophageal Reflux / drug therapy*,  physiopathology
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*,  physiopathology
Piperidines / pharmacology*,  therapeutic use
Prospective Studies
Serotonin Antagonists / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Piperidines; 0/Serotonin Antagonists; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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