| Effects of cisapride on QTc interval in neonates. | |
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MedLine Citation:
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PMID: 9462199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride. METHODS: QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996. RESULTS: Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestational age were lower. The prolongation of QTc interval above the arbitrary value of 0.450 (n = 7) was clinically asymptomatic and was significantly more common in the infants born with a gestational age < or = 33 weeks (n = 6). CONCLUSION: The findings indicate that cisapride accumulates in less mature neonates. Further pharmacokinetic studies are needed. |
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Authors:
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S Bernardini; D S Semama; F Huet; C Sgro; J B Gouyon |
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Publication Detail:
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Type: Case Reports; Clinical Trial; Journal Article |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 77 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-02-19 Completed Date: 1998-02-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: ENGLAND |
Other Details:
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Languages: eng Pagination: F241-3 Citation Subset: AIM; IM |
Affiliation:
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Centre Hospitalier Universitaire, Dijon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cisapride Electrocardiography / drug effects* Gastroesophageal Reflux / drug therapy*, physiopathology Gestational Age Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / drug therapy*, physiopathology Male Piperidines / pharmacology*, therapeutic use Prospective Studies Serotonin Antagonists / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 0/Serotonin Antagonists; 81098-60-4/Cisapride |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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