Document Detail

Effects of cisapride on QTc interval in neonates.
MedLine Citation:
PMID:  9462199     Owner:  NLM     Status:  MEDLINE    
AIM: Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride. METHODS: QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996. RESULTS: Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestational age were lower. The prolongation of QTc interval above the arbitrary value of 0.450 (n = 7) was clinically asymptomatic and was significantly more common in the infants born with a gestational age < or = 33 weeks (n = 6). CONCLUSION: The findings indicate that cisapride accumulates in less mature neonates. Further pharmacokinetic studies are needed.
S Bernardini; D S Semama; F Huet; C Sgro; J B Gouyon
Related Documents :
6112419 - Outcome for infants of very low birthweight: survey of world literature.
9197869 - Significance of low birthweight for gestational age among very preterm infants.
2919859 - Birth dimensions in melanesian and indian fijians and their relationships with maternal...
14593879 - Racial differences in birthweight-specific neonatal mortality in alaska: 1987-1996.
9465549 - Recent trend of the decrease in mean birthweights of infants in the western provinces o...
17516309 - Premature infants: analysis of serum phosphate during the first 4 weeks of life.
10227739 - Toxicological consequences of feeding pcb congeners to infant rhesus (macaca mulatta) a...
22222549 - Combining hand techniques with electric pumping increases the caloric content of milk i...
21524759 - Detecting, studying, and treating autism early: the one-year well-baby check-up approach.
Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  77     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-19     Completed Date:  1998-02-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F241-3     Citation Subset:  AIM; IM    
Centre Hospitalier Universitaire, Dijon, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Electrocardiography / drug effects*
Gastroesophageal Reflux / drug therapy*,  physiopathology
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy*,  physiopathology
Piperidines / pharmacology*,  therapeutic use
Prospective Studies
Serotonin Antagonists / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Piperidines; 0/Serotonin Antagonists; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Iodine and hypothyroidism in neonates with congenital heart disease.
Next Document:  One week triple therapy for Helicobacter pylori: a multicentre comparative study. Lansoprazole Helic...