| Effects of cinnamaldehyde on the glucose transport activity of GLUT1. | |
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MedLine Citation:
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PMID: 20955755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is accumulating evidence that cinnamon extracts contain components that enhance insulin action. However, little is know about the effects of cinnamon on non-insulin stimulated glucose uptake. Therefore, the effects of cinnamaldehyde on the glucose transport activity of GLUT1 in L929 fibroblast cells were examined under both basal conditions and conditions where glucose uptake is activated by glucose deprivation. The data reveal that cinnamaldehyde has a dual action on the glucose transport activity of GLUT1. Under basal conditions it stimulates glucose uptake and reaches a 3.5 fold maximum stimulation at 2.0mM. However, cinnamaldehyde also inhibits the activation of glucose uptake by glucose deprivation in a dose dependent manner. Experiments with cinnamaldehyde analogs reveal that these activities are dependent on the α,β-unsaturated aldehyde structural motif in cinnamaldehyde. The inhibitory, but not the stimulatory activity of cinnamaldehyde was maintained after a wash-recovery period. Pretreatment of cinnamaldehyde with thiol-containing compounds, such as β-mercaptoethanol or cysteine, blocked the inhibitory activity of cinnamaldehyde. These results suggest that cinnamaldehyde inhibits the activation of GLUT1 by forming a covalent link to target cysteine residue/s. This dual activity of cinnamaldehyde on the transport activity of GLUT1 suggests that cinnamaldehyde is not a major contributor to the anti-diabetic properties of cinnamon. |
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Authors:
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Christina Plaisier; Alexandra Cok; Jordan Scott; Adeleye Opejin; Kelsey T Bushhouse; Mathew J Salie; Larry L Louters |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-16 |
Journal Detail:
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Title: Biochimie Volume: 93 ISSN: 1638-6183 ISO Abbreviation: Biochimie Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-11 Completed Date: 2011-04-20 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 1264604 Medline TA: Biochimie Country: France |
Other Details:
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Languages: eng Pagination: 339-44 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of Chemistry and Biochemistry, Calvin College, 3201 Burton SE, Grand Rapids, MI 49546, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrolein
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analogs & derivatives*,
chemistry,
pharmacology Animals Biological Transport / drug effects Cell Line Dose-Response Relationship, Drug Fibroblasts / drug effects, metabolism Glucose / metabolism* Glucose Transporter Type 1 / metabolism* Mice Sulfhydryl Compounds / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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R15 DK08193-1A1/DK/NIDDK NIH HHS; R15 DK081931-01A1/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucose Transporter Type 1; 0/Sulfhydryl Compounds; 104-55-2/cinnamic aldehyde; 107-02-8/Acrolein; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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