| Effects of cilazapril, a novel angiotensin converting enzyme inhibitor, on the structure of pulmonary arteries of rats exposed to chronic hypoxia. | |
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MedLine Citation:
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PMID: 1708054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic hypoxia is known to be associated with a thickening of the media of pulmonary arteries. The goal of the present study was to assess if cilazapril, a novel long-acting angiotensin converting enzyme (ACE) inhibitor, could prevent this thickening. For this purpose, three groups of rats were studied. One group was kept in normal room air. Two other groups were exposed to chronic hypoxia (inspired fraction of oxygen equal to 8% during 4 weeks). One group of hypoxic rats was treated with placebo and the other group received cilazapril (as food admixture of approximately 3 mg/kg/day). After 4 weeks, rats were anesthetized and pulmonary artery pressure and hematocrit measured. Then, the lungs were perfused and fixed and morphometry of the pulmonary arteries was performed. Hypoxia induced an increase in pulmonary artery pressure and hematocrit associated with a dramatic increase in the thickness of the media of the pulmonary arteries. Cilazapril completely prevented the thickening of the media of the pulmonary arteries but did not significantly decrease the pulmonary artery pressure or right ventricular weight. |
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Authors:
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J P Clozel; C Saunier; D Hartemann; W Fischli |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 17 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-05-23 Completed Date: 1991-05-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 36-40 Citation Subset: IM |
Affiliation:
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Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd., Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology*,
therapeutic use Animals Anoxia / complications* Body Weight / drug effects, physiology Cilazapril Heart / anatomy & histology Hemodynamics / drug effects Hypertrophy / etiology, prevention & control Organ Size / drug effects, physiology Pulmonary Artery / anatomy & histology, drug effects*, pathology, physiology Pyridazines / pharmacology*, therapeutic use Rats |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Pyridazines; 92077-78-6/Cilazapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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