Document Detail


Effects of cigarette smoking on the ultrastructure of rat thoracic aorta and its ability to produce prostacyclin.
MedLine Citation:
PMID:  6758180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following exposure of rats to graded doses of fresh cigarette smoke, the aortic endothelium examined by scanning electron microscopy regularly showed alterations. These essentially consisted of areas of blebbing and microvillus-like projections from the luminal surface, and the presence in the majority of cases, of micro-thrombi in the low shear areas just proximal to intercostal branches. Aortas from rats exposed to smoke showed a reduction in prostacyclin production in vitro and platelets from these animals aggregated more readily than did those of controls.
Authors:
R M Pittilo; I J Mackie; P M Rowles; S J Machin; N Woolf
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  48     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  173-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / metabolism,  ultrastructure*
Blood Platelets / ultrastructure
Endothelium / ultrastructure
Epoprostenol / biosynthesis*
Male
Microscopy, Electron, Scanning
Platelet Adhesiveness
Platelet Aggregation
Prostaglandins / biosynthesis*
Prostaglandins F / biosynthesis
Rats
Rats, Inbred Strains
Smoking*
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins F; 35121-78-9/Epoprostenol; 745-62-0/prostaglandin F1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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