Document Detail

Effects of cigarette smoking on heart rate variability and plasma N-terminal pro-B-type natriuretic peptide in healthy subjects: is there the relationship between both markers?
MedLine Citation:
PMID:  18426439     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cigarette smoking increased the risk of acute cardiac events related with endothelial dysfunction and increased sympathetic activity. Impaired autonomic nervous activity is recognized as a considerable symptom of cardiac dysfunction and is strongly associated with increased risk overall mortality. METHODS: A total of 75 healthy habitual smokers (40 female, 35 male, mean age 36.5 +/- 8.5 years), and 73 non-smokers subjects (45 female, 28 male, mean age 34.6 +/- 7.2 years) were studied. LF and LF/HF ratio were significantly higher in smokers than in non-smokers. On the contrary, SDNN, SDANN, RMSSD, and HF values were lower in smokers compared to those in non-smokers. Not the duration of smoking but the number of cigarettes smoked per day was correlated with the HRV parameters and NT-pro BNP. Furthermore, the average levels of NT-pro BNP were found to be positively correlated with LF, LF/HF and inversely correlated with SDNN, SDANN, RMSSD and HF. RESULTS: As a result, smoking impaires sympathovagal balance and decreases the heart rate variability in healthy subjects. And even a one cigarette smoking leads to overt sympathetic excitation. Furthermore, smoking results in an increase in NT-proBNP levels and the changes in adrenergic nervous system and NT-proBNP levels are well correlated. CONCLUSION: These findings could contribute to the higher rate of cardiovascular events in smokers.
Omer Alyan; Fehmi Kacmaz; Ozcan Ozdemir; Orhan Maden; Serkan Topaloglu; Cemal Ozbakir; Fatma Metin; Aziz Karadede; Erdogan Ilkay
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  13     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-44     Citation Subset:  IM    
Department of Cardiology, Faculty of Medicine, Diyarbakir, Dicle University, Diyarbakir, Turkey.
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MeSH Terms
Biological Markers / analysis
Cardiovascular Diseases / epidemiology,  etiology,  physiopathology
Case-Control Studies
Cohort Studies
Electrocardiography, Ambulatory
Enzyme-Linked Immunosorbent Assay
Heart Rate / physiology*
Logistic Models
Middle Aged
Natriuretic Peptide, Brain / analysis,  blood*
Peptide Fragments / analysis,  blood*
Reference Values
Sensitivity and Specificity
Smoking / adverse effects*
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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