Document Detail

Effects of cigarette smoking on duodenal ulcer healing and relapse rate.
MedLine Citation:
PMID:  7759964     Owner:  NLM     Status:  MEDLINE    
104 duodenal ulcer patients were classified into non-smokers (76) and smokers (28). Their age range was between 14-72 years. They were randomly treated with cimetidine (28 non-smokers and 8 smokers), colloidal bismuth (27 non-smokers and 10 smokers) and sucralfate (21 non-smokers and 10 smokers). Follow-up endoscopic examination at 4, 6 and 8 weeks showed that overall healing rates were better in the non-smokers than in the smokers (64.5% against 46.4% at 4 weeks and 92.1% against 67.8% at 6 weeks) and almost all ulcers had healed at the end of 8 weeks (100% in non-smokers and 96.4% in smokers). Among non-smokers, there were no statistically significant differences in the healing rates by any medication at any period of time. Among smokers, colloidal bismuth had significant better healing rate at 6 weeks over cimetidine and sucralfate. (p = 0.04 and p = 0.041 respectively). Overall relapse rates were higher among smokers (32.1%) than non-smokers (10.5%). Of the 3 medications, sucralfate had the lowest relapse rate in both smokers (20%) and non-smokers (9.5%), while colloidal bismuth had the highest relapse rates (40% for smokers and 11.1% for non-smokers).
S Boonyapisit; S Manatsathit; U Kachintorn; T Tanwandee; Y Sattawatthamrong; O Chinapak
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  77     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-06-23     Completed Date:  1995-06-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  THAILAND    
Other Details:
Languages:  eng     Pagination:  566-71     Citation Subset:  IM    
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
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MeSH Terms
Bismuth / therapeutic use*
Cimetidine / therapeutic use*
Duodenal Ulcer / drug therapy*
Middle Aged
Sucralfate / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Colloids; 51481-61-9/Cimetidine; 54182-58-0/Sucralfate; 7440-69-9/Bismuth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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