Document Detail

Effects of cigarette smoke in mice wound healing is strain dependent.
MedLine Citation:
PMID:  18098035     Owner:  NLM     Status:  MEDLINE    
It has been clinically and experimentally shown that cigarette smokers suffer from impaired wound healing, but the mechanisms that lead to the alterations are not well understood. The aim of this study was to investigate if the effects of cigarette smoke exposure on excisional cutaneous wound healing are different depending on the strain (Swiss, BALB/c and C57BL/6 mice) studied. Male mice were exposed to smoke of nine whole cigarettes per day, 3 times/day, daily, for 10 days. In the 11th day a full-thickness excisional wound was performed. Control group was sham-exposed and also had a full-thickness excisional wound. The cigarette smoke exposure protocol was performed until euthanasia. Animals were euthanatized 14 days after wounding. Wound contraction was evaluated 7 and 14 days after lesion. Sections were stained with hematoxylin-eosin, Sirius red or toluidine blue and immunostained for alpha-smooth muscle actin. Smoke exposed animals presented delay in wound contraction, in fibroblastic and inflammatory cells recruitment and in myofibroblastic differentiation; those alterations were strain dependent. Cigarette smoke exposure also affected mast cells recruitment and neoepidermis thickness. In conclusion, the present study demonstrated that the effects of cigarette smoke in mice cutaneous wound healing are related to mice strain studied.
Juliana F Cardoso; Bruna R Souza; Thaís P Amadeu; Samuel S Valença; Luís Cristóvão M S Porto; Andréa M A Costa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicologic pathology     Volume:  35     ISSN:  0192-6233     ISO Abbreviation:  Toxicol Pathol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-02-21     Revised Date:  2012-01-05    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  890-6     Citation Subset:  IM    
Histology and Embryology Department, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
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MeSH Terms
Collagen / analysis
Epidermis / pathology
Interleukin-8 / biosynthesis
Mast Cells / pathology
Mice, Inbred BALB C
Mice, Inbred C57BL
Smoke / adverse effects*
Species Specificity
Tobacco / toxicity*
Wound Healing*
Reg. No./Substance:
0/Interleukin-8; 0/Smoke; 9007-34-5/Collagen

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