| Effects of cigarette smoke and 3-methylcholanthrene on the disposition of phencyclidine and its N-ethylamine analogue in the isolated perfused lung of rats. | |
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MedLine Citation:
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PMID: 4071555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The isolated perfused lung (IPL) of rats were used to examine the pulmonary disposition and metabolism of radiolabeled phencyclidine (PCP) and N-ethyl-1-phenylcyclohexylamine (PCE). The IPL removed PCP and PCE from the perfusate and converted them to free and conjugated metabolites. At the conclusion of a 1-h perfusion, the lung accumulated at least 20% of the administered radioactivity and metabolized more than 30% of the added drug. Pretreatment of rats with 3-MC or cigarette smoke enhanced significantly PCP and PCE metabolism by the IPL. The concentration of conjugated PCE metabolite in the perfusate of the IPL was increased significantly by both 3-MC and cigarette smoke pretreatments whereas the concentration of conjugated PCP metabolite was not affected by cigarette smoke exposure and increased only slightly after 3-MC pretreatment. Pretreatment of rats with 3-MC or cigarette smoke also altered the amount of radioactivity accumulated by the lung tissue at the conclusion of a 1-h perfusion. Inasmuch as PCP and PCE are often abused by humans via smoke inhalation, a significant amount of these drugs may be stored or metabolized by the lung. |
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Authors:
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F C Law; S Chakrabarti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology Volume: 37 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-01-10 Completed Date: 1986-01-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 275-84 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atmosphere Exposure Chambers Cyclohexylamines / metabolism* Injections, Intraperitoneal Lung / drug effects, metabolism* Male Methylcholanthrene / pharmacology* Phencyclidine / metabolism* Plants, Toxic Rats Rats, Inbred Strains Smoke / adverse effects* Tobacco Tritium |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexylamines; 0/Smoke; 10028-17-8/Tritium; 2201-15-2/N-ethyl-1-phenylcyclohexylamine; 56-49-5/Methylcholanthrene; 77-10-1/Phencyclidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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