| Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking. | |
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MedLine Citation:
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PMID: 12417964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: The relative contribution of sensory and pharmacological variables in regulating craving and smoking remains unclear. Rapid smoking procedures and denicotinized cigarettes can be used to further disentangle these factors, and to explore the relationship between craving and smoking. OBJECTIVE: The present study examined the role of nicotine and sensory cues in mediating craving and smoking, and the relationship between craving and smoking. METHODS: Participants ( n=15) engaged in one session each of rapid smoking (up to nine cigarettes with puffs taken every 6 s) and normal paced smoking with nicotinized and denicotinized cigarettes (total of four sessions). During the next 3 h, craving and withdrawal assessments and smoking opportunities were scheduled every 15 min. Plasma nicotine levels were measured at baseline, immediately and 15 min after the smoking interventions, and subsequently at the time when the participant first chose to smoke. RESULTS: Craving ratings were equally suppressed immediately after all conditions. After self-paced conditions, both types of cigarettes produced equivalent effects on latency to smoke. Latency to smoke was significantly longer after rapid smoking of nicotinized cigarettes compared to all other conditions. Finally, changes in craving were associated with choices to smoke. CONCLUSIONS: The sensory cues associated with smoking suppressed craving ratings regardless of the smoking pace or nicotine content. Only at high doses did nicotine levels play an additional role in acutely suppressing smoking behavior. Small elevations in craving ratings were associated with choices to smoke. |
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Authors:
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Jesse Dallery; Elisabeth J Houtsmuller; Wallace B Pickworth; Maxine L Stitzer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2002-10-31 |
Journal Detail:
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Title: Psychopharmacology Volume: 165 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-01-09 Completed Date: 2003-04-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 172-80 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Florida, P.O. Box 112250, Gainesville, FL 32611, USA. dallery@ufl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cues Dose-Response Relationship, Drug Humans Middle Aged Motivation* Neurologic Examination / drug effects Nicotine / adverse effects*, pharmacokinetics, pharmacology Reaction Time / drug effects Smoking / blood, psychology* Substance Withdrawal Syndrome / blood, psychology* |
| Grant Support | |
ID/Acronym/Agency:
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DA03893/DA/NIDA NIH HHS; DA131125/DA/NIDA NIH HHS; T32 DA07209/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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