Document Detail

Effects of cibenzoline on cardiac function and metabolism in the rat heart--lung preparation.
MedLine Citation:
PMID:  11298178     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Although there is concern that cibenzoline, an antidysrhythmic drug for the treatment of ventricular and supraventricular dysrhythmias, may be associated with dose-dependent inhibition of myocardial contractility there are few reports about the relationship between myocardial metabolism and cardiac function when it is used. The present study was designed to investigate the effects of cibenzoline on cardiac function and metabolism. The effects of cibenzoline on cardiac function and myocardial metabolism were assessed in the isolated rat heart-lung preparation. METHODS: Thirty-two male Wistar-ST rats were divided into four groups: control, and those to receive cibenzoline, either 300, 900 or 3000 ng mL(-1). The cibenzoline was administered into the perfusate 5 min after the start of perfusion. Heart rates in the 3000 ng mL(-1) group were significantly lower than those in the control group. Cardiac output in the 3000 ng mL(-1) group at 15 and 30 min was significantly lower than in the control group. In all groups, values for %LV dP/dt max (the ratio of values at each time to those at 5 min) at 20, 25, 30 min were significantly higher than at 5 min. Myocardial adenosine triphosphate concentration in the 3000 ng mL(-1) group was significantly lower than in controls. There was no difference between groups in the lactate/pyruvate ratio. CONCLUSION: The therapeutic range of cibenzoline has few effects on cardiac function and metabolism, although concentrations 10 times greater may cause a deterioration in myocardial metabolism.
A Furuya; M Kume; S Kashimoto; T Kumazawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  18     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-12     Completed Date:  2001-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  184-8     Citation Subset:  IM    
Department of Anaesthesiology, Yamanashi Medical University, Shimokato 1110, Tamaho-cho, Nakakoma-gun, Yamanashi, Japan.
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MeSH Terms
Adenosine Diphosphate / metabolism
Adenosine Monophosphate / metabolism
Adenosine Triphosphate / metabolism
Anti-Arrhythmia Agents / pharmacology*
Cardiac Output / drug effects
Dose-Response Relationship, Drug
Heart / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects
Imidazoles / pharmacology*
Lactic Acid / metabolism
Lung / physiology*
Myocardium / metabolism*
Pyruvic Acid / metabolism
Rats, Wistar
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Imidazoles; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 53267-01-9/cifenline; 56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate; 61-19-8/Adenosine Monophosphate

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