| Effects of chronic treatment with honokiol in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 20190404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was performed to evaluate the antihypertensive effects of honokiol in vivo in spontaneously hypertensive rats (SHR). The effects of honokiol were investigated by determination of the blood pressure, vascular reactivity, oxidative parameters, and histologic change in the aorta. Long-term administration of honokiol (400 mg/kg/d) to SHR decreased systolic blood pressure significantly. Honokiol (200, 400 mg/kg/d) enhanced the aortic relaxation in response to acetylcholine after 49-d treatment, but had no significant effects on the relaxation to sodium nitroprusside. The oral administration of honokiol significantly increased the plasma level of NO(2(-))/NO(3(-)), but decreased the level of malondialdehyde in liver of SHR compared with the control vehicle. In addition, SHR administered honokiol showed significant reductions in the elastin bands and media thickness in the aorta. These results suggest that chronic treatment with honokiol exerts an antihypertensive effect in SHR, and its vasorelaxant action and antioxidant properties may contribute to reducing the elevated blood pressure. |
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Authors:
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Gen-Shui Zhang; Ru-Jun Wang; Hai-Ning Zhang; Gui-Ping Zhang; Miao-Shan Luo; Jian-Dong Luo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 33 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 427-31 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Guangzhou Medical University, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Antihypertensive Agents / pharmacology, therapeutic use* Antioxidants / pharmacology, therapeutic use* Aorta / drug effects, pathology Biphenyl Compounds / pharmacology, therapeutic use* Blood Pressure / drug effects Elastin / metabolism Hypertension / drug therapy* Lignans / pharmacology, therapeutic use* Liver / metabolism Magnolia / chemistry* Malondialdehyde / metabolism Nitrates / blood Nitrites / blood Nitroprusside / pharmacology Plant Extracts / pharmacology, therapeutic use* Rats Rats, Inbred SHR Vasodilator Agents / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Antioxidants; 0/Biphenyl Compounds; 0/Lignans; 0/Nitrates; 0/Nitrites; 0/Plant Extracts; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 35354-74-6/honokiol; 51-84-3/Acetylcholine; 542-78-9/Malondialdehyde; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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