Document Detail


Effects of chronic treatment with honokiol in spontaneously hypertensive rats.
MedLine Citation:
PMID:  20190404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was performed to evaluate the antihypertensive effects of honokiol in vivo in spontaneously hypertensive rats (SHR). The effects of honokiol were investigated by determination of the blood pressure, vascular reactivity, oxidative parameters, and histologic change in the aorta. Long-term administration of honokiol (400 mg/kg/d) to SHR decreased systolic blood pressure significantly. Honokiol (200, 400 mg/kg/d) enhanced the aortic relaxation in response to acetylcholine after 49-d treatment, but had no significant effects on the relaxation to sodium nitroprusside. The oral administration of honokiol significantly increased the plasma level of NO(2(-))/NO(3(-)), but decreased the level of malondialdehyde in liver of SHR compared with the control vehicle. In addition, SHR administered honokiol showed significant reductions in the elastin bands and media thickness in the aorta. These results suggest that chronic treatment with honokiol exerts an antihypertensive effect in SHR, and its vasorelaxant action and antioxidant properties may contribute to reducing the elevated blood pressure.
Authors:
Gen-Shui Zhang; Ru-Jun Wang; Hai-Ning Zhang; Gui-Ping Zhang; Miao-Shan Luo; Jian-Dong Luo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  33     ISSN:  1347-5215     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  427-31     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Guangzhou Medical University, PR China.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Antihypertensive Agents / pharmacology,  therapeutic use*
Antioxidants / pharmacology,  therapeutic use*
Aorta / drug effects,  pathology
Biphenyl Compounds / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Elastin / metabolism
Hypertension / drug therapy*
Lignans / pharmacology,  therapeutic use*
Liver / metabolism
Magnolia / chemistry*
Malondialdehyde / metabolism
Nitrates / blood
Nitrites / blood
Nitroprusside / pharmacology
Plant Extracts / pharmacology,  therapeutic use*
Rats
Rats, Inbred SHR
Vasodilator Agents / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Antioxidants; 0/Biphenyl Compounds; 0/Lignans; 0/Nitrates; 0/Nitrites; 0/Plant Extracts; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 35354-74-6/honokiol; 51-84-3/Acetylcholine; 542-78-9/Malondialdehyde; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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