Document Detail

Effects of chronic smoke exposure on the cardiovascular responses to acute nicotine infusion in the rat.
MedLine Citation:
PMID:  3371398     Owner:  NLM     Status:  MEDLINE    
Rats were exposed daily to cigarette smoke for 17-22 weeks in order to characterize mean arterial pressure and regional hemodynamic effects of chronic smoke exposure and to determine if cardiovascular reactivity to acute nicotine infusions is altered by chronic smoke exposure. Urethane-anesthetized animals were instrumented with miniaturized pulsed-Doppler flow probes on the iliac and mesenteric vascular beds. Under resting conditions sham-smoked and smoke-exposed animals had similar levels of mean arterial pressure and mesenteric blood flow; however, resting heart rate was lower in the smoke-exposed group, while iliac blood flow was elevated in the smoke-exposed group. Acute nicotine infusion (6.25, 12.5 and 25 micrograms/kg per min) produced equivalent, dose-dependent pressor effects as well as increases in iliac and mesenteric resistance in sham and smoke-exposed groups. Thus, chronic cigarette smoke-exposure in rats may exert significant cardiovascular effects other than on arterial pressure such as lowered heart rate and elevated blood flow to skeletal muscle beds, while cardiovascular responses to nicotine are not altered by chronic smoke-exposure.
K W Barron; C M Heesch; B P Fleming; C Y Chien; J N Diana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  146     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-07-12     Completed Date:  1988-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  237-45     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Kentucky, Lexington 40546-0236.
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects
Iliac Artery
Mesenteric Arteries
Nicotine / toxicity*
Rats, Inbred Strains
Regional Blood Flow / drug effects
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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