| Effects of chronic protein-calorie malnutrition on small intestinal repair after an acute bacterial enteritis: a study in infant rabbits. | |
| | |
MedLine Citation:
|
PMID: 3131727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to determine if recovery of intestinal function in infant rabbits subjected to protein-calorie malnutrition was delayed as a result of inflammatory injury induced by an experimental bacterial enteritis. Rabbits were malnourished by expanding litter size at 7 days of age and infecting undernourished animals and dietary controls with Yersinia enterocolitica at either 17 or 21 days of age. Intestinal morphology and function were evaluated in infected and noninfected animals from both dietary groups at 27 days of age. Undernutrition alone significantly reduced animal weight, small intestinal weight, segmental jejunal and ileal mucosal weight, villus height, crypt depth, disaccharidase activities, mucosal protein and DNA contents, but increased ileal short-circuited glucose-stimulated Na+ absorption compared to controls. The jejunum of undernourished rabbits at 6 days postinfection exhibited an intestinal injury, as evidenced by a mild inflammatory infiltrate and further reductions in villus height, mucosal weight, lactase activity, protein and DNA content, not seen in infected dietary controls. Jejunal recovery was complete by 10 days postinfection. In the ileum of infected animals of both dietary groups at 6 days post-infection, a severe inflammatory response, decreased villus height, elongated crypts, and depressed stimulation of Na+ absorption by glucose was observed. By 10 days after infection, while recovery was nearly complete in dietary controls, intestinal damage persisted in the undernourished rabbits, as evidenced by absent glucose-stimulated Na+ absorption, continued severe inflammation and microabscess formation. We conclude that intestinal injury is more severe and chronic in the undernourished, compared to dietary control infant rabbits subjected to an acute bacterial enteritis. |
| | |
Authors:
|
J D Butzner; D G Gall |
Related Documents
:
|
9693207 - Diet supplemented with yoghurt or milk fermented by lactobacillus casei dn-114 001 stim... 3007057 - Effect of diet on intestinal xylose absorption in dogs. 19095767 - Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in ... 15036167 - The effects of a normal protein diet on levodopa plasma kinetics in advanced parkinson'... 20920687 - Treating mixed hyperlipidemia and the atherogenic lipid phenotype for prevention of car... 12012627 - Assessment of the metabolic tolerance in postmenopausal women over a 1-year period of t... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatric research Volume: 23 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1988 Apr |
Date Detail:
|
Created Date: 1988-06-30 Completed Date: 1988-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 408-13 Citation Subset: IM |
Affiliation:
|
Intestinal Diseases Research Unit, University of Calgary, Alberta, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Animals Animals, Newborn Chronic Disease DNA / analysis Enteritis / etiology, pathology* Intestinal Mucosa / analysis, anatomy & histology Intestine, Small / anatomy & histology, metabolism*, pathology Organ Size Protein-Energy Malnutrition / physiopathology* Proteins / analysis Rabbits Wound Healing Yersinia Infections / pathology* Yersinia enterocolitica |
| Chemical | |
Reg. No./Substance:
|
0/Proteins; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Atenolol enhances growth hormone release to exogenous growth hormone-releasing hormone but fails to ...
Next Document: Development of the gastrointestinal mucosal barrier: changes in phospholipid head groups and fatty a...