| Effects of chronic prazosin treatment on the renin-angiotensin-aldosterone system in man. | |
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MedLine Citation:
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PMID: 7309905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of chronic prazosin treatment (3 mg/day for three weeks) on plasma renin activity (PRA) and plasma aldosterone (PA) levels were evaluated in 12 hypertensive patients, under conditions of metabolic balance. After three weeks of drug administration no significant change occurred in PRA as well as PA levels, with respect to pretreatment values, both in basal conditions and following 2 hours of ambulation. No change was observed in heart rate, while a fall in both systolic (P less than 0.02) and diastolic (P less than 0.05) blood pressure occurred in supine as well as in deambulation-stimulating condition. A mild increase in body weight (P less than 0.05) and a decrease in serum sodium (P less than 0.05) was induced by prazosin treatment. These findings are in keeping with the pharmacologic properties of prazosin, which is a selective blocker of postsynaptic alpha adrenoreceptors and therefore lowers vascular resistance without reflex sympathetic overactivity. The moderate volume expansion after prazosin does not appear to be aldosterone mediated. |
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Authors:
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C Barbieri; C Ferrari; R Caldara; P Rampini; R M Crossignani; M Bergonzi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 21 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 418-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Drug Administration Schedule Female Heart Rate / drug effects Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Prazosin / pharmacology* Quinazolines / pharmacology* Renin-Angiotensin System / drug effects* Sodium / blood |
| Chemical | |
Reg. No./Substance:
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0/Quinazolines; 19216-56-9/Prazosin; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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