Document Detail


Effects of chronic nicotine and haloperidol administration on muscarinic receptor-mediated phosphoinositide turnover in rat brain slices.
MedLine Citation:
PMID:  1365667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Muscarinic receptor-mediated phosphoinositide (PI) turnover in rat brain slices was assessed after chronic administration of nicotine (12 mg/kg/day) or haloperidol decanoate (1.5 mg/kg/day), either alone or in combination, for 6 weeks. Nicotine alone did not significantly alter carbachol-induced inositol monophosphate (IP1) accumulation in the frontal cortex, but did result in a significant increase in the hippocampus, and in a decrease in the striatum. Haloperidol alone attenuated carbachol-stimulated IP1 accumulation in all three brain regions. Chronic treatment with combined nicotine and haloperidol resulted in no significant change in carbachol-sensitive IP1 accumulation in either the frontal cortex or hippocampus but did result in a decrease in the striatum. The results suggest significant cross-talk between cholinergic and dopaminergic systems in affecting PI metabolism.
Authors:
R Li; L L Wing; D G Kirch; R J Wyatt; D M Chuang
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  109     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1992  
Date Detail:
Created Date:  1995-02-23     Completed Date:  1995-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  248-50     Citation Subset:  IM    
Affiliation:
Neuropsychiatry Branch, National Institute of Mental Health, Neuroscience Center at Saint Elizabeths, Washington, DC 20032.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry / drug effects*
Carbachol / pharmacology
Frontal Lobe / drug effects,  metabolism
Haloperidol / pharmacology*
Hippocampus / drug effects,  metabolism
Male
Neostriatum / drug effects,  metabolism
Nicotine / pharmacology*
Phosphatidylinositols / metabolism*
Rats
Rats, Sprague-Dawley
Receptors, Muscarinic / drug effects*
Chemical
Reg. No./Substance:
0/Phosphatidylinositols; 0/Receptors, Muscarinic; 51-83-2/Carbachol; 52-86-8/Haloperidol; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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