Document Detail


Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis).
MedLine Citation:
PMID:  17297637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: The effects of chronic moderate alcohol consumption on cardiac function are not understood. Acute stress may affect cardiac function by shifting autonomic cardiac regulation in favor of the sympathetic nervous system. Although alcohol consumption often increases at times of stress, the interactive effects of stress and chronic moderate alcohol consumption on cardiac regulation have not been studied. OBJECTIVES AND METHODS: The objective was to assess the effects of long-term (1-2 years) moderate (a two-drink/day equivalent, 5 days/week) alcohol consumption on heart rate (HR) variability under normal and acutely stressful conditions in small stable groups of ovariectomized adult cynomolgus monkeys (Macaca fascicularis). Monkeys were trained to voluntarily drink their daily alcohol dose (<30 min), and blood levels were determined an hour later. The animals were acutely stressed by removal from the home cage to a novel environment for 30 min. HR in freely moving subjects was recorded via telemetry in the home cage and the novel environment. RESULTS: Acute stress increased HR, decreased HR variability, and decreased the high frequency component of the power spectrum suggesting reduced parasympathetic cardiac modulation. Chronic moderate alcohol consumption decreased HR variability and the low frequency components of the power spectrum. When stressed, monkeys with a history of chronic moderate alcohol consumption had higher HRs than the controls. CONCLUSIONS: HR dynamics in monkeys rapidly respond to acute stress. Chronic moderate alcohol consumption may be deleterious to cardiac function. HR response to stress may be exaggerated when accompanied by a history of chronic moderate alcohol consumption.
Authors:
Carol A Shively; Joseph E Mietus; Kathleen A Grant; Ary L Goldberger; Allyson J Bennett; Stephanie L Willard
Related Documents :
15595287 - Physiological responses during a submaximal cycle test in chronic fatigue syndrome.
8514687 - Muscle sympathetic nerve responses to prolonged one-legged exercise.
2097677 - Cardiorespiratory and perceptual responses to arm crank and wheelchair exercise using v...
12883897 - Effect of menstrual cycle and gender on ventilatory and heart rate responses at the ons...
9628207 - Qigong yangsheng as a complementary therapy in the management of asthma: a single-case ...
1119917 - Excitation overflow: an electromyographic investigation.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-02-13
Journal Detail:
Title:  Psychopharmacology     Volume:  192     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-26     Completed Date:  2007-07-10     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  IM    
Affiliation:
Department of Pathology (Comparative Medicine), Wake Forest University School of Medicine, Winston-Salem, NC 27157-1040, USA. cshively@wfubmc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alcoholism / physiopathology*
Analysis of Variance
Animals
Autonomic Nervous System / physiology
Central Nervous System Depressants / pharmacology*
Ethanol / pharmacology*
Female
Heart Rate / drug effects*
Macaca fascicularis
Stress, Psychological / physiopathology*
Sympathetic Nervous System / physiology
Telemetry
Grant Support
ID/Acronym/Agency:
P41 RR013622/RR/NCRR NIH HHS; P50 AA11997/AA/NIAAA NIH HHS; R01 AA11204/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents.
Next Document:  Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord...