Document Detail

Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model.
MedLine Citation:
PMID:  7509496     Owner:  NLM     Status:  MEDLINE    
1. To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied. 2. The levels of 5-HT, 5-hydroxyindoleacetic acid, 5-HTP, 5-HT turnover and their response to 5-HTP administration all exhibited no change following mianserin treatment. 3. The Bmax value of the high affinity site of the 5-HT-1A receptor increased and the Bmax value of 5-HT-2 receptor decreased with no change in the low affinity site of the 5-HT-1A receptor nor in the 5-HT-1B receptor. 4. The response to 5-HTP administration showed no change in any of these receptors. 5. These results suggest that the chronic mianserin administration might block both the 5-HT-2 and 5-HT-1A receptors in the 5-hydroxytryptophan depression model.
J Akiyoshi; K Tsuchiyama; Y Mizobe; M Nakamura; H Kuranaga; H Nagayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  18     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-03-31     Completed Date:  1994-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  165-79     Citation Subset:  IM    
Department of Neuropsychiatry, Oita Medical University, Japan.
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MeSH Terms
5-Hydroxytryptophan / metabolism,  pharmacology*
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
Brain Chemistry / drug effects
Cerebral Cortex / drug effects,  metabolism
Depression / chemically induced,  metabolism*,  psychology
Hydroxyindoleacetic Acid / metabolism
Membranes / drug effects,  metabolism
Mianserin / pharmacology*
Radioligand Assay
Rats, Wistar
Receptors, Serotonin / drug effects,  metabolism*
Serotonin / metabolism*
Reg. No./Substance:
0/Receptors, Serotonin; 24219-97-4/Mianserin; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 56-69-9/5-Hydroxytryptophan; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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