Document Detail

Effects of chronic lung inflammation on tryptophan metabolism in piglets.
MedLine Citation:
PMID:  15206750     Owner:  NLM     Status:  MEDLINE    
A fundamental question in animal nutrition is the amino acid requirement induced by inflammation and immune response. The aim of the present experiment was to study the effect of chronic lung inflammation induced by injection of complete Freund adjuvant on amino acid metabolism in pigs. For 10 days, we compared plasma haptoglobine and amino acid concentrations of piglets with chronic lung inflammation (CFA) with those of pair-fed littermate healthy pigs (CONTROL). Tryptophan was the only amino acid for which the plasma concentration was continously decreasing and did not reach the control level at the end of the experimental period. We suggested that an increase in tryptophan catabolism under indoleamine 2, 3 dioxygenase activation and/or tryptophan incorporation into acute phase protein could explained the decrease in plasma tryptophan concentration in pigs suffuring from chronic lung inflammation.
Delphine Melchior; Nathalie Le Floc'h; Bernard Sève
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  527     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2003  
Date Detail:
Created Date:  2004-06-21     Completed Date:  2004-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  359-62     Citation Subset:  IM    
INRA Unité Mixte de Recherches sur le Veau et le Porc Domaine de la prise 35590 St-Gilles, France.
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MeSH Terms
Chronic Disease
Freund's Adjuvant / administration & dosage
Kynurenine / blood
Pneumonia / etiology,  metabolism,  veterinary*
Sus scrofa
Swine Diseases / etiology,  metabolism*
Tryptophan / metabolism*
Reg. No./Substance:
343-65-7/Kynurenine; 73-22-3/Tryptophan; 9007-81-2/Freund's Adjuvant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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