| Effects of chronic liver disease on bone mineral density and bone metabolism markers in postmenopausal women. | |
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MedLine Citation:
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PMID: 16051419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Patients with chronic liver disease (CLD) have an increased prevalence of osteoporosis. However, there is limited information about the effects of end-stage liver disease on bone metabolism and bone mineral density values in postmenopausal women. The aim of this study was to investigate the effects of chronic liver disease on bone mineral density (BMD) and bone metabolism markers in postmenopausal women. METHODS: We studied BMD by using dual-energy X-ray absorptiometry (DEXA), biochemical markers of bone turnover and calcium-parathyroid hormone (PTH)-Vitamin D axis in 22 postmenopausal women with CLD. Control group consisted of randomly recruited 30 healthy postmenopausal women. RESULTS: Based on WHO criteria, the prevalence of osteoporosis was significantly higher in patients with CLD (72 versus 33%) compared to healthy postmenopausal women. Bone loss was more significant at the lumbar spine than femur in the study group. Urinary excretion of bone resorption marker deoxypyridinoline was increased significantly in patients with CLD. There were no significant differences in bone formation markers (osteocalcin and bone alkaline phosphatase) between the groups. CONCLUSIONS: CLD increases the prevalence of osteoporosis in postmenopausal women, particularly in the lumbar spine. Increased bone resorption seems to be the main reason for osteoporosis in these patients. We suggest that treatment strategies should be improved in these women to protect them from subsequent fractures. |
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Authors:
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Sevinc Uretmen; Mert Gol; Dilek Cimrin; Esra Irmak |
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Publication Detail:
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Type: Journal Article Date: 2005-07-26 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 123 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-01 Completed Date: 2006-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 67-71 Citation Subset: IM |
Affiliation:
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Izmir Ataturk Research and Training Hospital, Department of Internal Medicine, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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blood,
metabolism Amino Acids / metabolism, urine Bilirubin / metabolism Biological Markers / metabolism* Bone Density / physiology* Bone Remodeling / physiology Bone and Bones / metabolism* Calcium / metabolism Chronic Disease Cross-Sectional Studies Female Femur / anatomy & histology, physiology Humans Liver Diseases / complications, metabolism* Lumbar Vertebrae / anatomy & histology, physiology Middle Aged Osteocalcin / blood, metabolism Osteoporosis, Postmenopausal / etiology, metabolism Parathyroid Hormone / blood Phosphorus / metabolism Postmenopause / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biological Markers; 0/Parathyroid Hormone; 104982-03-8/Osteocalcin; 635-65-4/Bilirubin; 7440-70-2/Calcium; 7723-14-0/Phosphorus; 90032-33-0/deoxypyridinoline; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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