Document Detail

Effects of chronic food restriction on prodynorphin-derived peptides in rat brain regions.
MedLine Citation:
PMID:  7895045     Owner:  NLM     Status:  MEDLINE    
Chronic food restriction produces a variety of physiological and behavioral adaptations including a potentiation of the reinforcing effect of food, drugs and lateral hypothalamic electrical stimulation. Previous work in this laboratory has revealed that the lowering of self-stimulation threshold by food restriction is reduced by mu- and kappa-selective opioid antagonists. In the present study, the effect of chronic food restriction on levels of three prodynorphin-derived peptides, namely dynorphin A1-17 (A1-17), dynorphin A1-8 (A1-8) and dynorphin B1-13 (B1-13) were measured in eleven brain regions known to be involved in appetite, taste and reward. Food restriction increased levels of A1-17 in dorsal medial (+19.6%), ventral medial (+24.2%) and medial preoptic (+82.9%) hypothalamic areas. Levels of A1-17 decreased in the central nucleus of the amygdala (-35.1%). Food restriction increased levels of A1-8 in nucleus accumbens (+34.4%), bed nucleus of the stria terminalis (+24.5%) and lateral hypothalamus (+41.9%). Food restriction had no effect on levels of B1-13. A1-17 is highly kappa-preferring and the brain regions in which levels increased all have a high ratio of kappa: mu and delta receptors. A1-8 is less discriminating among opioid receptor types and the brain regions in which levels increased have a low ratio of kappa: mu and delta receptors. The present results suggest that food restriction alters posttranslational processing within the dynorphin A domain of the prodynorphin precursor, possibly leading to a change in the balance between kappa and non-kappa opioid receptor stimulation in specific brain regions.
Y Berman; L Devi; K D Carr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  664     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-04-24     Completed Date:  1995-04-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Department of Psychiatry, New York University Medical Center, NY 10016.
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MeSH Terms
Dynorphins / metabolism
Enkephalins / metabolism*
Hypothalamic Hormones / metabolism
Neuropeptides / metabolism*
Peptide Fragments / metabolism
Protein Precursors / metabolism*
Rats, Sprague-Dawley
Time Factors
Grant Support
Reg. No./Substance:
0/Enkephalins; 0/Hypothalamic Hormones; 0/Neuropeptides; 0/Peptide Fragments; 0/Protein Precursors; 0/dynorphin B (1-13); 74913-18-1/Dynorphins; 75790-53-3/dynorphin (1-8); 93443-35-7/preproenkephalin

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