Document Detail


Effects of chronic fluvoxamine on ethanol- and food-maintained behaviors.
MedLine Citation:
PMID:  16647721     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute treatment with fluvoxamine reduces responding for ethanol more than responding for food. However, pharmacotherapy for alcoholism is likely to require chronic treatment. These experiments were performed to assess the effects of chronic fluvoxamine on ethanol- and food-maintained behaviors. Effects of chronic fluvoxamine (10 and 17.8 mg/kg/dayx30 days) on ethanol- and food-maintained responding were compared to responding during saline treatment in four Sprague-Dawley rats responding for ethanol and food under a multiple fixed-ratio 5, fixed-ratio 5 schedule. In two subjects, chronic fluvoxamine reduced ethanol-maintained responding more than food-maintained responding; however this effect was transient. In another subject, treatment persistently decreased food-maintained responding relative to ethanol-maintained responding. Finally, in one subject, fluvoxamine nonspecifically disrupted responding for food and ethanol. Similar to results in humans, outbred Sprague-Dawley rats had differential responses to chronic fluvoxamine. The effect was transient in rats that responded favorably (greater reduction of ethanol relative to food responding), while response reductions persisted throughout treatment in rats that responded unfavorably (greater reduction of food relative to ethanol or nonspecific reductions).
Authors:
Brett C Ginsburg; R J Lamb
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-04-07
Journal Detail:
Title:  Life sciences     Volume:  79     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-09-28     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1228-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*
Central Nervous System Depressants / pharmacology*
Conditioning, Operant / drug effects*
Ethanol / pharmacology*
Fluvoxamine / pharmacology*
Food*
Individuality
Male
Rats
Rats, Sprague-Dawley
Serotonin Uptake Inhibitors / pharmacology*
Grant Support
ID/Acronym/Agency:
AA012337/AA/NIAAA NIH HHS; R01 AA012337/AA/NIAAA NIH HHS; R01 AA012337-07/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Serotonin Uptake Inhibitors; 3K9958V90M/Ethanol; O4L1XPO44W/Fluvoxamine
Comments/Corrections

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