Document Detail


Effects of chronic fentanyl administration on physical performance of aged rats.
MedLine Citation:
PMID:  20951790     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is growing concern over the increasing use of opioids to treat chronic pain in the elderly primarily because of the potential increased sensitivity to the adverse side effects. Here, we use a preclinical model (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) to describe the outcome of chronic fentanyl administration (1.0mg/kg/day) on various physiological and behavioral measures. Continuous fentanyl administration resulted in an initial decrease in food consumption, followed by the development of tolerance to this effect over a 4-week period and a subsequent increase in food consumption during withdrawal. This change in food consumption was associated with decreases in body weight (predominantly due to a loss of fat mass) that was maintained through early withdrawal. After 1 month of withdrawal, only the 12-month old animals had fully regained body weight. Fentanyl administration resulted in a decrease in grip strength and an increase in locomotor activity that did not differ across age groups. There was no effect of fentanyl administration on rotarod performance. These results demonstrate that while there is a delayed recovery of body mass with age, the observed changes in behavioral responses are uniform across ages.
Authors:
Jeremiah D Mitzelfelt; Jameson P Dupree; Dong-oh Seo; Christy S Carter; Drake Morgan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-15
Journal Detail:
Title:  Experimental gerontology     Volume:  46     ISSN:  1873-6815     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-07     Completed Date:  2011-03-25     Revised Date:  2013-07-10    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL 32610, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging*
Analgesics, Opioid / pharmacology*
Animals
Behavior, Animal / drug effects*
Body Composition / drug effects
Body Weight / drug effects
Drug Evaluation, Preclinical
Drug Tolerance / physiology
Eating / drug effects
Fentanyl / pharmacology*
Hand Strength
Male
Motor Activity / drug effects*
Muscle Strength / drug effects
Rats
Rats, Inbred BN
Rats, Inbred F344
Grant Support
ID/Acronym/Agency:
P30AG028740/AG/NIA NIH HHS; R01AG24526/AG/NIA NIH HHS; R21 DA023022/DA/NIDA NIH HHS; R21 DA023022-02/DA/NIDA NIH HHS; R21DA023022/DA/NIDA NIH HHS; T32 AG00196/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 437-38-7/Fentanyl
Comments/Corrections

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