Document Detail

Effects of chronic ethanol treatment on amino acid uptake and enzyme activities in the lactating rat mammary gland.
MedLine Citation:
PMID:  2883546     Owner:  NLM     Status:  MEDLINE    
The effects of chronic ethanol consumption on mammary gland amino acid uptake at the 15th day of lactation in the rat have been studied. Ethanol treatment decreased the arterial levels of Ala, Asp, Gly, Pro, Lys and Met, and increased those of Gln and alpha-amino-butyrate. Chronic ethanol treatment produced a decrease in the arteriovenous differences of Asp, Thr, Arg, Met and Phe, and increased those of Ala, Gln, Gly, Pro and Tyr. The combination of the calculated values of relative extraction and the arteriovenous differences indicate that these alterations in amino acid uptake are related to changes in the transport process for Ala, Asp, Thr, Pro, Arg, Asn, Gly, Tyr, and Phe, and that the alterations in the arteriovenous differences of Gln, Lys and Met are due to the affected arterial levels of these amino acids. Measurements of enzymatic activities in the mammary gland show that these alterations in the amino acid transport process cannot be ascribed to changes in the gamma-glutamyl cycle.
O Viñas; S Vilaro; E Herrera; X Remesar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  40     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1745-9     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism*
Biological Transport / drug effects
Ethanol / pharmacology*
Mammary Glands, Animal / drug effects,  metabolism*
Rats, Inbred Strains
gamma-Glutamyltransferase / analysis
Reg. No./Substance:
0/Amino Acids; 64-17-5/Ethanol; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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