Document Detail


Effects of chronic ethanol exposure on cardiac receptor-adenylyl cyclase coupling: studies in cultured embryonic chick myocytes and ethanol fed rats.
MedLine Citation:
PMID:  1789384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethanol effects in the brain appear to be mediated at least in part by an alteration in receptor-effector coupling via guanine nucleotide-binding regulatory proteins (G proteins). To test the hypothesis that a similar pathway participates in the cardiotoxic effects of ethanol, we assessed the effects of chronic ethanol on two commonly used experimental models: embryonic chick myocytes in culture and ventricular myocardium from chronically fed rats. Ethanol had no effect on either the function or quantity of G proteins as assessed by effector-stimulated adenylyl cyclase activity and the levels of ADP-ribosylation substrates. In contrast, effector-stimulated adenylyl cyclase activity was significantly altered in the liver of ethanol-fed rats. These results suggest that receptor-effector coupling via G proteins in our two cardiac models is insensitive to ethanol and that ethanol effects may be species or organ specific.
Authors:
R S Blumenthal; I W Flinn; O Proske; D G Jackson; R G Tena; M C Mitchell; A M Feldman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  15     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-20     Completed Date:  1992-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1077-83     Citation Subset:  IM    
Affiliation:
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
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MeSH Terms
Descriptor/Qualifier:
ADP-Ribosylation Factors
Adenylate Cyclase / drug effects*,  physiology*
Animals
Cells, Cultured
Chick Embryo
Ethanol / toxicity*
GTP-Binding Proteins / drug effects*,  physiology*
Heart / drug effects*
Male
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
AA 06865/AA/NIAAA NIH HHS; HL 39719/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol; EC 3.6.1.-/GTP-Binding Proteins; EC 3.6.5.2/ADP-Ribosylation Factors; EC 4.6.1.1/Adenylate Cyclase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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