Document Detail


Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue.
MedLine Citation:
PMID:  2502039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of chronic ethanol consumption on enzyme systems directly involved in carcinogen activation and detoxification were studied in rat upper alimentary tract tissue. Microsomal cytochrome P-450 (P-450) levels and glutathione levels as well as glutathione transferase and UDP-glucuronic acid transferase (UDPGT) activities were measured in mucosa scraped from esophagus, forestomach and glandular stomach of rats which had been pair-fed ethanol or dextrimaltose-containing diets. Esophageal and forestomach P-450 levels were increased in the ethanol-fed rats. The ethanol diet also produced a small but significant increase in esophageal glutathione transferase levels. Glutathione levels and UDPGT activity were unaffected. Since P-450 is directly involved in the activation of many chemical carcinogens, these results are consistent with the hypothesis that the increase in upper alimentary tract cancer risk associated with alcohol abuse is due, at least in part, to ethanol's altering the balance between carcinogen activation and detoxification.
Authors:
F Farinati; C S Lieber; A J Garro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  13     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-60     Citation Subset:  IM    
Affiliation:
Department of Microbiology, City University of New York Medical School, New York 10031.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / physiology*
Animals
Carcinogens / pharmacokinetics*
Cytochrome P-450 Enzyme System / metabolism*
Enzyme Activation / drug effects
Esophagus / drug effects,  enzymology*
Gastric Mucosa / enzymology
Glucuronosyltransferase / metabolism*
Glutathione / metabolism
Glutathione Transferase / metabolism*
Male
Metabolic Detoxication, Drug
Rats
Stomach / drug effects,  enzymology*
Grant Support
ID/Acronym/Agency:
AA03509/AA/NIAAA NIH HHS; RR03060/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Carcinogens; 70-18-8/Glutathione; 9035-51-2/Cytochrome P-450 Enzyme System; EC 2.4.1.17/Glucuronosyltransferase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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