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Effects of chronic aluminum exposure on memory through multiple signal transduction pathways.
MedLine Citation:
PMID:  21787618     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effects of chronic aluminum (Al) exposure on memory of rats by recording long-term potentiation (LTP) induction in CA1 region of Schaffer collateral (SC) of hippocampus and observing the changes of key LTP induction-related kinases.
METHODS: Forty weaned Wistar rats were divided into 4 groups ad libitum, each group 10 rats. Three groups were fed with 0.2%, 0.4% and 0.6% AlCl(3) in drinking water for three months individually to set up the aluminum exposure models and the rest group was the control. After behavioral test, electrophysiological recordings were made at area CA1 from hippocampal SC branch followed by biochemical examination for several key kinases involved in LTP induction and formation.
RESULTS: Chronic exposure of Al significantly decrease the activities of protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) and reduced the expression levels of extracellular signal-regulated kinases (ERK1/2) and Ca(2+)-calmodulin dependent protein kinase II (CaMKII) in hippocampus, attenuating the population spike (PS) amplitude of LTP from the hippocampal CA1 region, causing impaired memory abilities of rats.
CONCLUSIONS: Aluminum accumulation in the hippocampus affects several crucial kinases involved in LTP induction and formation, resulting in impairment of memory.
Authors:
Biao Wang; Wei Xing; Yan Zhao; Xin Deng
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Publication Detail:
Type:  Journal Article     Date:  2010-03-12
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  29     ISSN:  1872-7077     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2011-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences of China Medical University, No. 92, Beier Road, Heping District, Shenyang 110001, China.
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