| Effects of chronic administration of bilobalide on amino acid levels in mouse brain. | |
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MedLine Citation:
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PMID: 12396079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously demonstrated that 4-day-treatment of mice with bilobalide, a sesquiterpene of Ginkgo biloba L., increases GABA levels in mouse brain, but, effects of chronic treatment with it are not clear. To study effects of chronic treatment of mice with bilobalide on amino acid levels in the brain, we determined the levels of aspartate, glutamate, serine, glutamine, glycine, taurine and GABA in the hippocampus, striatum and cortex. Bilobalide (3 mg/kg/day) was administered orally to 4-week-old mice for 40 days. Bilobalide treatment resulted in a significant increase in the levels of glutamate, aspartate, gamma-aminobutyric acid (GABA), and glycine in the hippocampus of mice compared with the control. An increased level of glycine after bilobalide treatment was also detected in the striatum. In the cortex, bilobalide increased the GABA level, whereas it decreased the level of aspartate. These changes in the levels of various amino acids may be involved in the broad spectrum of pharmacological activities of the extract of Ginkgo biloba on the central nervous system. |
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Authors:
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Keiko Sasaki; Shinichi Hatta; Keiji Wada; Masahiro Itoh; Teruki Yoshimura; Masanobu Haga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cellular and molecular biology (Noisy-le-Grand, France) Volume: 48 ISSN: 0145-5680 ISO Abbreviation: Cell. Mol. Biol. (Noisy-le-grand) Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-24 Completed Date: 2003-04-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9216789 Medline TA: Cell Mol Biol (Noisy-le-grand) Country: France |
Other Details:
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Languages: eng Pagination: 681-4 Citation Subset: IM |
Affiliation:
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Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, lshikari-Tobetsu, Japan. ksasaki@hoku-iryo-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Amino Acids / drug effects*, metabolism Animals Brain / drug effects*, metabolism Cerebral Cortex / drug effects, metabolism Corpus Striatum / drug effects, metabolism Cyclopentanes / administration & dosage, pharmacology* Diterpenes* Furans / administration & dosage, pharmacology* Ginkgolides Hippocampus / drug effects, metabolism Male Mice Neuroprotective Agents / administration & dosage, pharmacology* Taurine / drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Cyclopentanes; 0/Diterpenes; 0/Furans; 0/Ginkgolides; 0/Neuroprotective Agents; 107-35-7/Taurine; 33570-04-6/bilobalide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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