| Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 20885007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chromium picolinate [Cr(pic)(3)] is a nutritional supplement widely promoted to exert beneficial metabolic effects in patients with type 2 diabetes/impaired glucose tolerance. Frequent comorbidities in these individuals include systemic hypertension, abnormal vascular function and ischemic heart disease, but information on the effects of the supplement on these aspects is sparse. Utilizing male spontaneously hypertensive rats (SHR), we examined the potential impact of Cr(pic)(3) on blood pressure, vascular reactivity and myocardial ischemia-reperfusion injury (IRI). Dietary Cr(pic)(3) supplementation (as 10 mg chromium/kg diet for six weeks) did not affect blood pressure of the SHR. Also, neither norepinephrine (NE) and potassium chloride (KCl)-induced contractility nor sodium nitroprusside (SNP)-induced relaxation of aortic smooth muscle from the SHR was altered by Cr(pic)(3) treatment. However, Cr(pic)(3) augmented endothelium-dependent relaxation of aortas, produced by acetylcholine (ACh), and this effect was abolished by N-nitro-L-arginine methyl ester (L-NAME), suggesting induction of nitric oxide (NO) production/release. Treatment with Cr(pic)(3) did not affect baseline coronary flow rate and rate-pressure-product (RPP) or infarct size following regional IRI. Nonetheless, Cr(pic)(3) treatment was associated with improved coronary flow and recovery of myocardial contractility and relaxation following ischemia-reperfusion insult. In conclusion, dietary Cr(pic)(3) treatment of SHR alters neither blood pressure nor vascular smooth muscle reactivity but causes enhancement of endothelium-dependent vasorelaxation associated with NO production/release. Additionally, while the treatment does not affect infarct size, it improves functional recovery of the viable portion of the myocardium following IRI. |
| | |
Authors:
|
Worku Abebe; Jun Yao Liu; Hereward Wimborne; Mahmood S Mozaffari |
Related Documents
:
|
1692947 - Cardiovascular effects of sk&f 104078, a novel alpha-adrenoceptor antagonist, in normot... 14553967 - Renal renin-angiotensin system activity in naturally reared and cross-fostered spontane... 9406167 - Adriamycin depresses in vivo and in vitro phosphatidylethanolamine n-methylation in rat... 10100497 - Radiotelemetric versus externalized catheter monitoring of blood pressure: effect of va... 6996627 - Long term comparative study of guanfacine and alpha-methyldopa in essential hypertension. 8441867 - Effect of extracellular fluid volume expansion on avian lung fluid balance. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pharmacological reports : PR Volume: 62 ISSN: 1734-1140 ISO Abbreviation: Pharmacol Rep Publication Date: 2010 Jul-Aug |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: 2011-01-12 Revised Date: 2011-11-28 |
Medline Journal Info:
|
Nlm Unique ID: 101234999 Medline TA: Pharmacol Rep Country: Poland |
Other Details:
|
Languages: eng Pagination: 674-82 Citation Subset: IM |
Affiliation:
|
Department of Oral Biology, CL 2136, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912-1128, USA. wabebe@mail.mcg.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / drug effects, metabolism Blood Pressure / drug effects* Dietary Supplements Endothelium, Vascular / drug effects, metabolism Hypertension / physiopathology Male Muscle Contraction / drug effects Muscle Relaxation / drug effects Muscle, Smooth, Vascular / drug effects, metabolism Myocardial Infarction / drug therapy*, etiology Myocardial Reperfusion Injury / physiopathology* Myocardium / pathology Nitric Oxide / metabolism Picolinic Acids / pharmacology* Rats Rats, Inbred SHR |
| Grant Support | |
ID/Acronym/Agency:
|
1R21AT003012-01A2/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Picolinic Acids; 10102-43-9/Nitric Oxide; 98-98-6/picolinic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intracerebroventricular administration of riluzole prevents morphine-induced apoptosis in the lumbar...
Next Document: Evaluation of terfenadine and ketoconazole-induced QT prolongation in conscious telemetered guinea p...