Document Detail


Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive rats.
MedLine Citation:
PMID:  20885007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromium picolinate [Cr(pic)(3)] is a nutritional supplement widely promoted to exert beneficial metabolic effects in patients with type 2 diabetes/impaired glucose tolerance. Frequent comorbidities in these individuals include systemic hypertension, abnormal vascular function and ischemic heart disease, but information on the effects of the supplement on these aspects is sparse. Utilizing male spontaneously hypertensive rats (SHR), we examined the potential impact of Cr(pic)(3) on blood pressure, vascular reactivity and myocardial ischemia-reperfusion injury (IRI). Dietary Cr(pic)(3) supplementation (as 10 mg chromium/kg diet for six weeks) did not affect blood pressure of the SHR. Also, neither norepinephrine (NE) and potassium chloride (KCl)-induced contractility nor sodium nitroprusside (SNP)-induced relaxation of aortic smooth muscle from the SHR was altered by Cr(pic)(3) treatment. However, Cr(pic)(3) augmented endothelium-dependent relaxation of aortas, produced by acetylcholine (ACh), and this effect was abolished by N-nitro-L-arginine methyl ester (L-NAME), suggesting induction of nitric oxide (NO) production/release. Treatment with Cr(pic)(3) did not affect baseline coronary flow rate and rate-pressure-product (RPP) or infarct size following regional IRI. Nonetheless, Cr(pic)(3) treatment was associated with improved coronary flow and recovery of myocardial contractility and relaxation following ischemia-reperfusion insult. In conclusion, dietary Cr(pic)(3) treatment of SHR alters neither blood pressure nor vascular smooth muscle reactivity but causes enhancement of endothelium-dependent vasorelaxation associated with NO production/release. Additionally, while the treatment does not affect infarct size, it improves functional recovery of the viable portion of the myocardium following IRI.
Authors:
Worku Abebe; Jun Yao Liu; Hereward Wimborne; Mahmood S Mozaffari
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  62     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-12     Revised Date:  2013-12-19    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  674-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / drug effects,  metabolism
Blood Pressure / drug effects*
Dietary Supplements
Endothelium, Vascular / drug effects,  metabolism
Hypertension / physiopathology
Male
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / drug effects,  metabolism
Myocardial Infarction / drug therapy*,  etiology
Myocardial Reperfusion Injury / physiopathology*
Myocardium / pathology
Nitric Oxide / metabolism
Picolinic Acids / pharmacology*
Rats
Rats, Inbred SHR
Grant Support
ID/Acronym/Agency:
1R21AT003012-01A2/AT/NCCAM NIH HHS; R21 AT003012/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Picolinic Acids; 31C4KY9ESH/Nitric Oxide; QZV2W997JQ/picolinic acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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