| Effects of chorioamnionitis on the fetal lung. | |
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MedLine Citation:
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PMID: 22954262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Very preterm infants are commonly exposed to a chronic, often asymptomatic, chorioamnionitis that is diagnosed by histologic evaluation of the placenta only after delivery. The reported effects of these exposures on fetal lungs are inconsistent because exposure to different organisms, durations of exposure, and fetal/maternal responses affect outcomes. In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia. |
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Authors:
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Alan H Jobe |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in perinatology Volume: 39 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-07 Completed Date: 2013-02-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 441-57 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML#7029, Cincinnati, OH 45229-3039, USA. alan.jobe@cchmc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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adverse effects Animals Bronchopulmonary Dysplasia / physiopathology Chorioamnionitis / immunology, microbiology, physiopathology* Female Humans Infant, Newborn Infant, Premature Lung / embryology*, growth & development, physiopathology Pregnancy Prenatal Exposure Delayed Effects Respiratory Distress Syndrome, Newborn / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD057869/HD/NICHD NIH HHS; R01 HD072842/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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