Document Detail


Effects of chorioamnionitis on the fetal lung.
MedLine Citation:
PMID:  22954262     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Very preterm infants are commonly exposed to a chronic, often asymptomatic, chorioamnionitis that is diagnosed by histologic evaluation of the placenta only after delivery. The reported effects of these exposures on fetal lungs are inconsistent because exposure to different organisms, durations of exposure, and fetal/maternal responses affect outcomes. In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia.
Authors:
Alan H Jobe
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  39     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-07     Completed Date:  2013-02-11     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-57     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML#7029, Cincinnati, OH 45229-3039, USA. alan.jobe@cchmc.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / adverse effects
Animals
Bronchopulmonary Dysplasia / physiopathology
Chorioamnionitis / immunology,  microbiology,  physiopathology*
Female
Humans
Infant, Newborn
Infant, Premature
Lung / embryology*,  growth & development,  physiopathology
Pregnancy
Prenatal Exposure Delayed Effects
Respiratory Distress Syndrome, Newborn / physiopathology
Grant Support
ID/Acronym/Agency:
R01 HD057869/HD/NICHD NIH HHS; R01 HD072842/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Delivery room respiratory management of the term and preterm infant.
Next Document:  Initial Respiratory Support of Preterm Infants: The Role of CPAP, the INSURE Method, and Noninvasive...