| Effects of cholestyramine and diet on small intestinal histomorphometry in rats. | |
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MedLine Citation:
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PMID: 9547867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reports on the effects of cholestyramine on small intestinal structure of rats have produced contradictory data about changes in mucosal histomorphometry, perhaps due to interacting effects of dietary composition. In order to identify effects of cholestyramine and diet on structure of the small intestines, 40 male rats were divided into 4 groups of 10 and fed 1 of each of the following diets for 1 month: standard diet, purified fiber-free diet, standard diet + 2% cholestyramine, or purified fiber-free diet + 2% cholestyramine. Serum concentrations of cholesterol and triglycerides were moderately increased in rats fed the purified fiber-free diet versus the standard diet. Neither total length nor weight of small intestine were affected by either diet or cholestyramine. Mucosal weight was affected by interactions between cholestyramine and diet, indicating that outcome depended upon modulating effects of both variables. Significant interactions were similarly detected among the variables of anatomic site, diet, and cholestyramine for many histomorphometric parameters of intestinal mucosa. Cholestyramine reduced total mucosal thickness in both jejunum and ileum and reduced villus height and villus:crypt ratio in the ileum. |
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Authors:
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J E Burkhardt; M L Biehl; K P Kowsz; E Kadyszewski; D O Fisher; R Ochoa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Toxicologic pathology Volume: 26 ISSN: 0192-6233 ISO Abbreviation: Toxicol Pathol Publication Date: 1998 Mar-Apr |
Date Detail:
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Created Date: 1998-06-04 Completed Date: 1998-06-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 271-5 Citation Subset: IM |
Affiliation:
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Department of Drug Safety Evaluation, Pfizer Central Research, Groton, Connecticut 06340, USA. John_E_Burkhardt@groton.pfizer.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / toxicity* Cholesterol / blood Cholestyramine Resin / toxicity* Diet* Ileum / drug effects, pathology Intestine, Small / drug effects*, pathology Jejunum / drug effects, pathology Male Organ Size / drug effects Rats Rats, Sprague-Dawley Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Triglycerides; 11041-12-6/Cholestyramine Resin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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