Document Detail

Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding.
MedLine Citation:
PMID:  17196207     Owner:  NLM     Status:  MEDLINE    
Cholesterol ester transfer protein (CETP) plays a key role in remodeling triglyceride-rich particles and high-density lipoproteins (HDL). We investigated CETP sequence variants in response to long-term overfeeding (100 days) in 12 pairs of male monozygotic twins (mean age+/-S.D.: 21+/-2 years). Body fat mass (FM), abdominal subcutaneous (ASF) and visceral fat (AVF), and plasma lipoproteins were determined. The CETP variants C>T/In9 (rs289714) and G>A/Ex14 (rs5882, or I405V) were investigated by RFLP-PCR methodologies. Before overfeeding, the CETP CC/In9 (n=18) genotype was associated with lower FM compared to the C>T/In9 heterozygotes. Overfeeding induced more FM and ASF accretion in C>T/In9 carriers (P<or=0.05). CETP V405V homozygotes (n=8) had lower BMI, FM, and ASF before overfeeding than those with the I405I (n=6) or I405V (n=10) genotypes. However, V405V subjects had the largest gain in AVF with overfeeding (P=0.02). Decreases from baseline were significantly different across the I405V genotypes for HDL-C, HDL-Apo AI, HDL(2), and HDL(3) (P<or=0.05). Our data suggests that CETP sequence variation contributes to the undesirable changes in adiposity and HDL-C levels when exposed to excessive calorie consumption and may be potentially helpful to identify individuals with the metabolic syndrome who are at higher risk of cardiovascular disease.
Margarita Terán-García; Jean-Pierre Després; Angelo Tremblay; Claude Bouchard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-12-28
Journal Detail:
Title:  Atherosclerosis     Volume:  196     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-02-29     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  455-60     Citation Subset:  IM    
Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
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MeSH Terms
Adipose Tissue
Cholesterol Ester Transfer Proteins / genetics*
Cohort Studies
Diseases in Twins / genetics*
Genetic Predisposition to Disease
Hyperphagia* / genetics,  physiopathology
Obesity / genetics*
Polymorphism, Single Nucleotide / genetics*
Twins, Monozygotic
Weight Gain / genetics*
Grant Support
Reg. No./Substance:
0/CETP protein, human; 0/Cholesterol Ester Transfer Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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