| Effects of chlorpromazine on fixed-ratio responding: modification by fixed-interval discriminative stimuli. | |
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MedLine Citation:
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PMID: 3958665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of chlorpromazine (1 to 100 mg/kg) were assessed on two pigeons' responding under various modifications of a multiple schedule of food delivery. During a fixed-interval component, the first response after 5 min produced food; during the subsequent, fixed-ratio component, the 30th response produced food. Modifications of the schedule entailed changes in stimulus conditions imposed during the fixed-ratio component that did not systematically alter characteristics of performance under non-drug conditions. In the first phase of the experiment, distinctive visual stimuli were correlated with each schedule component (conventional multiple schedule); chlorpromazine produced small decreases in fixed-ratio responding (20% at 30 mg/kg). When each response during the fixed-ratio component produced the stimulus correlated with the fixed-interval schedule (fixed-interval discriminative stimulus) for 1.2 s, effects of chlorpromazine were not different from those under the conventional multiple schedule. Chlorpromazine produced greater decreases in fixed-ratio responding (55% at 30 mg/kg) when either the first response of each fixed ratio changed the stimulus correlated with the fixed-ratio schedule to the fixed-interval discriminative stimulus for the remainder of the fixed-ratio component, or when the fixed-interval discriminative stimulus was presented independently of responding according to a matched temporal sequence. When the fixed-interval discriminative stimulus was present continuously during the fixed-ratio component (mixed schedule), chlorpromazine produced even more substantial decreases in fixed-ratio responding (greater than 80% at 30 mg/kg). Effects of chlorpromazine on fixed-interval responding were also modified by the schedules of fixed-interval discriminative stimulus presentation. The effects of chlorpromazine were a joint function of the stimuli prevailing during the multiple schedule and the degree to which responding influenced these stimuli. |
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Authors:
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J M Witkin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the experimental analysis of behavior Volume: 45 ISSN: 0022-5002 ISO Abbreviation: J Exp Anal Behav Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-05-22 Completed Date: 1986-05-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0203727 Medline TA: J Exp Anal Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 195-205 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlorpromazine / pharmacology* Color Columbidae Conditioning, Operant / drug effects* Discrimination Learning / drug effects* Food Reinforcement Schedule* |
| Grant Support | |
ID/Acronym/Agency:
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GM-22683/GM/NIGMS NIH HHS; MH-14262/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-53-3/Chlorpromazine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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