Document Detail

Effects of chlorpromazine on fixed-ratio responding: modification by fixed-interval discriminative stimuli.
MedLine Citation:
PMID:  3958665     Owner:  NLM     Status:  MEDLINE    
Effects of chlorpromazine (1 to 100 mg/kg) were assessed on two pigeons' responding under various modifications of a multiple schedule of food delivery. During a fixed-interval component, the first response after 5 min produced food; during the subsequent, fixed-ratio component, the 30th response produced food. Modifications of the schedule entailed changes in stimulus conditions imposed during the fixed-ratio component that did not systematically alter characteristics of performance under non-drug conditions. In the first phase of the experiment, distinctive visual stimuli were correlated with each schedule component (conventional multiple schedule); chlorpromazine produced small decreases in fixed-ratio responding (20% at 30 mg/kg). When each response during the fixed-ratio component produced the stimulus correlated with the fixed-interval schedule (fixed-interval discriminative stimulus) for 1.2 s, effects of chlorpromazine were not different from those under the conventional multiple schedule. Chlorpromazine produced greater decreases in fixed-ratio responding (55% at 30 mg/kg) when either the first response of each fixed ratio changed the stimulus correlated with the fixed-ratio schedule to the fixed-interval discriminative stimulus for the remainder of the fixed-ratio component, or when the fixed-interval discriminative stimulus was presented independently of responding according to a matched temporal sequence. When the fixed-interval discriminative stimulus was present continuously during the fixed-ratio component (mixed schedule), chlorpromazine produced even more substantial decreases in fixed-ratio responding (greater than 80% at 30 mg/kg). Effects of chlorpromazine on fixed-interval responding were also modified by the schedules of fixed-interval discriminative stimulus presentation. The effects of chlorpromazine were a joint function of the stimuli prevailing during the multiple schedule and the degree to which responding influenced these stimuli.
J M Witkin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the experimental analysis of behavior     Volume:  45     ISSN:  0022-5002     ISO Abbreviation:  J Exp Anal Behav     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-22     Completed Date:  1986-05-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0203727     Medline TA:  J Exp Anal Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-205     Citation Subset:  IM    
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MeSH Terms
Chlorpromazine / pharmacology*
Conditioning, Operant / drug effects*
Discrimination Learning / drug effects*
Reinforcement Schedule*
Grant Support
Reg. No./Substance:

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