Document Detail

Effects of chlordiazepoxide on extinction and re-acquisition of operant behaviour in mice.
MedLine Citation:
PMID:  15187580     Owner:  NLM     Status:  MEDLINE    
Relatively little is known about the role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in extinction of appetitively motivated tasks. The benzodiazepine (BZ) chlordiazepoxide (CDP) was administered during extinction and re-acquisition of lever pressing by mice following food reinforced discrete-trial fixed-ratio 5 (FR-5) training. Typical FR behaviour was established during baseline training and persisted for several extinction sessions. There were 15 extinction sessions in all, followed by six re-acquisition sessions where food reinforcement was re-introduced. In a 2x2x2 between-group design, CDP (15 mg/kg) or vehicle injections were given prior to either the last two food reinforcement sessions and the first 10 extinction sessions, or the final five extinction sessions, or the six re-acquisition sessions. Initially CDP had no effect on the rate of extinction, but after several extinction sessions it significantly facilitated it. Surprisingly, if CDP was administered only after several sessions of extinction, it immediately produced facilitation. Thus the delayed effects of CDP are not due to drug accumulation. These data suggest that some neural change must occur before CDP can affect extinction processes. In re-acquisition sessions, CDP facilitated the reinstatement of food-reinforced lever pressing. Implications for neural and behavioural accounts of operant extinction are discussed.
D Shaw; G R Dawson; D S Reynolds; C McCabe; J C Leslie
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  15     ISSN:  0955-8810     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-09     Completed Date:  2004-12-08     Revised Date:  2009-07-07    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
School of Psychology, University of Ulster, Newtownabbey, Northern Ireland, UK.
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MeSH Terms
Appetitive Behavior / drug effects,  physiology
Chlordiazepoxide / administration & dosage,  pharmacology*
Conditioning, Operant / drug effects*,  physiology
Drug Administration Schedule
Extinction, Psychological / drug effects*,  physiology
GABA Modulators / administration & dosage,  pharmacology*
Mice, Inbred C57BL
Reinforcement (Psychology)
Time Factors
Reg. No./Substance:
0/GABA Modulators; 58-25-3/Chlordiazepoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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