Document Detail

Effects of chloral, chloralose and pentobarbitone on monoamine and (neuropeptide Y) NPY levels in various tissues in the rat.
MedLine Citation:
PMID:  1604044     Owner:  NLM     Status:  MEDLINE    
Sampling of blood or tissues in experimental animals need frequently a general anesthesia. Some anesthetic agents are known to modify plasma levels of catecholamines; moreover NPY is co-released with noradrenaline or adrenaline under certain conditions. Thus, we investigated the effect of three general anesthetic agents, chloral, chloralose and pentobarbital (pentobarbitone) on the levels of monoamines and NPY in rat hypothalamus, medulla, atria and adrenals. Monoamines were analysed by high pressure liquid chromatography using an electrochemical detection and NPY was measured by radioimmunoassay (immunoradiometric assay, IRMA). Chloralose or pentobarbitone did not affect monoamine tissue levels. In contrast, chloral increased 5-hydroxyindolacetic acid and to a lesser extent serotonin levels in the hypothalamus. NPY tissue levels did not change whatever the anesthetic used. These results must be taken into account in pharmacological or toxicological studies which need the use of a general anesthesia.
M Heimburger; N Pages; M Davy; C el Rawadi; Y Cohen; C Bohuon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  76     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-16     Completed Date:  1992-07-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  IM    
Laboratories de Toxicologie, Faculté de Pharmacie, Châtenay Malabry.
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MeSH Terms
Adrenal Glands / drug effects,  metabolism
Anesthetics / pharmacology*
Biogenic Monoamines / metabolism*
Catecholamines / metabolism
Chloral Hydrate / analogs & derivatives,  pharmacology
Chloralose / pharmacology
Hypothalamus / drug effects,  metabolism
Indoles / metabolism
Myocardium / metabolism
Neuropeptide Y / metabolism*
Pentobarbital / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Anesthetics; 0/Biogenic Monoamines; 0/Catecholamines; 0/Indoles; 0/Neuropeptide Y; 15879-93-3/Chloralose; 302-17-0/Chloral Hydrate; 75-87-6/trichloroacetaldehyde; 76-74-4/Pentobarbital

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