Document Detail

Effects of chest wall strapping on mechanical response to methacholine in humans.
MedLine Citation:
PMID:  16497846     Owner:  NLM     Status:  MEDLINE    
We examined the effects of chest wall strapping (CWS) on the response to inhaled methacholine (MCh) and the effects of deep inspiration (DI). Eight subjects were studied on 1 day with MCh inhaled without CWS (CTRL), 1 day with MCh inhaled during CWS (CWSon/on), and 1 day with MCh inhaled during temporary removal of CWS (CWSoff/on). On the CWSon/on day, MCh caused greater increases in pulmonary resistance, upstream resistance, dynamic elastance, residual volume, and greater decreases in maximal expiratory flow than on the CTRL day. On the CWSoff/on day, the changes in these parameters with MCh were not different from the CTRL day. Six of the subjects were again studied using the same protocol on CTRL and CWSon/on days, except that, on a third day, MCh was given after applying the CWS, but the measurements before and after the inhalation were made without CWS (CWSon/off). The latter sequence was associated with more severe airflow obstruction than during CTRL, but less than with CWSon/on. The bronchodilator effects of a DI were blunted when CWS was applied during measurements (CWSon/on and CWSoff/on) but not after it was removed (CWSon/off). We conclude that CWS is capable of increasing airway responsiveness only when it is applied during the inhalation of the constrictor agent. We speculate that breathing at low lung volumes induced by CWS enhances airway narrowing because the airway smooth muscle is adapted at a length at which the contractile apparatus is able to generate a force greater than normal.
Roberto Torchio; Carlo Gulotta; Claudio Ciacco; Alberto Perboni; Marco Guglielmo; Flavio Crosa; Mario Zerbini; Vito Brusasco; Robert E Hyatt; Riccardo Pellegrino
Related Documents :
3175346 - Airway responsiveness to exercise and ultrasonically nebulized distilled water in child...
9872836 - Airway and lung tissue mechanics in asthma. effects of albuterol.
18753466 - 8-isoprostane in exhaled breath condensate and exercise-induced bronchoconstriction in ...
16900236 - Airway distensibility in normal and asthmatic subjects and partitioning of the fowler d...
24093386 - Exercise may have only a moderate effect in treating depression.
2943716 - Diagnostic laparoscopy in the horse.
Publication Detail:
Type:  Journal Article     Date:  2006-02-23
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  101     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-09-12     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  430-8     Citation Subset:  IM    
Pneumologia-Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, Ospedale A. Carle, Via Carle, 12100 Confreria-Cuneo, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Airway Resistance / drug effects,  physiology
Bronchial Provocation Tests
Bronchoconstrictor Agents / pharmacology*
Inhalation / drug effects,  physiology
Lung / anatomy & histology
Lung Volume Measurements
Methacholine Chloride / pharmacology*
Middle Aged
Muscle Contraction / drug effects,  physiology
Muscle, Smooth / drug effects,  physiology
Residual Volume / drug effects,  physiology
Respiratory Function Tests
Respiratory Mechanics / drug effects,  physiology*
Thoracic Wall / physiology*
Reg. No./Substance:
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice...
Next Document:  Recognizing alcohol and drug abuse in patients with eating disorders.