| Effects of chest wall strapping on mechanical response to methacholine in humans. | |
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MedLine Citation:
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PMID: 16497846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of chest wall strapping (CWS) on the response to inhaled methacholine (MCh) and the effects of deep inspiration (DI). Eight subjects were studied on 1 day with MCh inhaled without CWS (CTRL), 1 day with MCh inhaled during CWS (CWSon/on), and 1 day with MCh inhaled during temporary removal of CWS (CWSoff/on). On the CWSon/on day, MCh caused greater increases in pulmonary resistance, upstream resistance, dynamic elastance, residual volume, and greater decreases in maximal expiratory flow than on the CTRL day. On the CWSoff/on day, the changes in these parameters with MCh were not different from the CTRL day. Six of the subjects were again studied using the same protocol on CTRL and CWSon/on days, except that, on a third day, MCh was given after applying the CWS, but the measurements before and after the inhalation were made without CWS (CWSon/off). The latter sequence was associated with more severe airflow obstruction than during CTRL, but less than with CWSon/on. The bronchodilator effects of a DI were blunted when CWS was applied during measurements (CWSon/on and CWSoff/on) but not after it was removed (CWSon/off). We conclude that CWS is capable of increasing airway responsiveness only when it is applied during the inhalation of the constrictor agent. We speculate that breathing at low lung volumes induced by CWS enhances airway narrowing because the airway smooth muscle is adapted at a length at which the contractile apparatus is able to generate a force greater than normal. |
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Authors:
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Roberto Torchio; Carlo Gulotta; Claudio Ciacco; Alberto Perboni; Marco Guglielmo; Flavio Crosa; Mario Zerbini; Vito Brusasco; Robert E Hyatt; Riccardo Pellegrino |
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Publication Detail:
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Type: Journal Article Date: 2006-02-23 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 101 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-19 Completed Date: 2006-09-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 430-8 Citation Subset: IM |
Affiliation:
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Pneumologia-Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, Ospedale A. Carle, Via Carle, 12100 Confreria-Cuneo, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance / drug effects, physiology Bronchial Provocation Tests Bronchoconstrictor Agents / pharmacology* Humans Inhalation / drug effects, physiology Lung / anatomy & histology Lung Volume Measurements Male Methacholine Chloride / pharmacology* Middle Aged Muscle Contraction / drug effects, physiology Muscle, Smooth / drug effects, physiology Residual Volume / drug effects, physiology Respiratory Function Tests Respiratory Mechanics / drug effects, physiology* Thoracic Wall / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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