Document Detail

Effects of chemicals on delayed matching behavior in pigeons. II: tolerance to the effects of diazepam and cross tolerance to phencyclidine.
MedLine Citation:
PMID:  6890185     Owner:  NLM     Status:  MEDLINE    
Pigeons were trained under a 2-sec matching to sample schedule. Diazepam, phencyclidine and pentobarbital all decreased matching accuracy. Chronic administration of diazepam after the session produced no effect on matching accuracy on the next day; however, two weeks of postsession diazepam administration produced tolerance to the effects of presession diazepam administration and cross tolerance to phencyclidine, but not to pentobarbital. After 6 weeks without chronic diazepam administration, both the tolerance to the effects of diazepam on matching accuracy and the cross tolerance to phencyclidine had disappeared.
D E McMillan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology     Volume:  3     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  138-41     Citation Subset:  IM    
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MeSH Terms
Diazepam / pharmacology*
Drug Tolerance
Learning / drug effects*
Pentobarbital / pharmacology
Phencyclidine / pharmacology*
Grant Support
02251//PHS HHS
Reg. No./Substance:
439-14-5/Diazepam; 76-74-4/Pentobarbital; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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