Document Detail


Effects of changes in the concentration of systemic progesterone on ions, amino acids and energy substrates in cattle oviduct and uterine fluid and blood.
MedLine Citation:
PMID:  20353728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Early embryo loss is a major factor affecting the conception rate in cattle. Up to 40% of cattle embryos die within 3 weeks of fertilisation while they are nutritionally dependent on oviduct and uterine fluids for their survival. Inadequate systemic progesterone is one of the factors contributing to this loss. We have characterised the effects of changes in systemic progesterone on amino acid, ion and energy substrate composition of oviduct and uterine fluids on Days 3 and 6, respectively, of the oestrus cycle in cattle. Oviduct and uterine fluids were collected in situ following infusion of progesterone. There was no effect of progesterone on oviduct fluid secretion rate; however, uterine fluid secretion rate was lowered. Progesterone increased uterine glucose, decreased oviduct sulfate and, to a lesser degree, oviduct sodium, but had no effect on any of the ions in the uterus. The most marked effect of progesterone was on oviducal amino acid concentrations, with a twofold increase in glycine, whereas in the uterus only valine was increased. These results provide novel information on the maternal environment of the early cattle embryo and provide further evidence of progesterone regulation of oviduct amino acid concentrations in cattle.
Authors:
S A Hugentobler; J M Sreenan; P G Humpherson; H J Leese; M G Diskin; D G Morris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  22     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  684-94     Citation Subset:  IM    
Affiliation:
Animal Bioscience Department, Teagasc, Mellows Campus, Athenry, Galway, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood,  metabolism*
Animals
Blood Glucose / metabolism
Body Fluids / metabolism*
Cattle / blood,  metabolism*
Estrous Cycle / blood,  drug effects,  metabolism
Fallopian Tubes / chemistry,  drug effects*,  metabolism*
Female
Ions / blood,  metabolism
Lactic Acid / blood,  metabolism
Progesterone / blood,  metabolism,  pharmacology*
Pyruvic Acid / blood,  metabolism
Regression Analysis
Uterus / chemistry,  metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Ions; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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