| Effects of centrally and systemically administered indomethacin on body temperature in exercising rats. | |
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MedLine Citation:
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PMID: 8342692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subcutaneous and intracerebroventricular (icv) injections of indomethacin were used to test whether prostaglandin synthesis is essential for the exercise-induced increase in a rat's body temperature. At an air temperature of 24 degrees C, male Wistar rats ran on a treadmill at 10-15 m/min 20 min after 300-micrograms icv injection or 60 min after 15-mg/kg sc injection of indomethacin or of control vehicle. The rectal temperature (Tre) of control rats in 17 control experiments increased by 1.0 degree C during exercise, whereas the Tre of the rats pretreated with intracerebroventricular indomethacin increased by only 0.4 degrees C. Threshold Tre for tail vasodilation was significantly lower in rats pretreated with indomethacin than the control rats (38.4 +/- 0.1 vs. 38.9 +/- 0.1 degrees C), but O2 uptake did not differ between indomethacin-pretreated and control rats. Subcutaneous injection of indomethacin did not affect the body temperature, tail vasomotor activity, or O2 uptake of exercising rats. Intracerebroventricular indomethacin did not affect Tre or tail vasomotor activity of rats resting at ambient temperatures of 24 and 28 degrees C. Present results suggest that prostaglandin synthesis is required for the vasoconstrictive effect of exercise on skin blood vessels and thus for the exercise-induced elevation of body temperature. |
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Authors:
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H Tanaka; M Yanase-Fujiwara; K Kanosue |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 265 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-08-27 Completed Date: 1993-08-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R230-4 Citation Subset: IM |
Affiliation:
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Department of Physiology, Osaka University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects* Brain / physiology* Indomethacin / administration & dosage, pharmacology* Injections, Intraventricular Injections, Subcutaneous Male Physical Exertion* Rats Rats, Wistar Rest Tail / blood supply Vasomotor System / drug effects |
| Chemical | |
Reg. No./Substance:
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53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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