Document Detail

Effects of central histamine receptors blockade on GABA(A) agonist-induced food intake in broiler cockerels.
MedLine Citation:
PMID:  18817165     Owner:  NLM     Status:  MEDLINE    
In this study, the effect of intracerebroventricular (i.c.v) injection of H1, H2 and H3 antagonists on feed intake induced by GABA(A) agonist was evaluated. In Experiment 1, the animals received chloropheniramine, a H1 antagonist and then muscimol, a GABA(A) agonist. In Experiment 2, chickens received famotidine, a H2 receptor antagonist, prior to injection of muscimol. Finally in Experiment 3, the birds were injected with thioperamide, a H3 receptor antagonist and muscimol. Cumulative food intake was measured 15, 30, 45, 60, 90, 120, 150 and 180 min after injections. The results of this study indicated that effects of muscimol on food intake inhibited by pretreatment with chloropheneramine maleate (p < or = 0.05), significantly, while the famotidine and thioperamide were ineffective. These results suggest the existence of H1-receptor mediated histamine-GABA(A) receptor interaction on food intake in broiler cockerels.
Zendehdel Morteza; Babapour Vahhab; Jonaidi Hossein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  11     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-09-26     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  416-21     Citation Subset:  IM    
Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran.
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MeSH Terms
Chickens / physiology*
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
GABA Agonists / pharmacology*
Histamine Antagonists / administration & dosage,  pharmacology*
Injections, Intraventricular
Reg. No./Substance:
0/GABA Agonists; 0/Histamine Antagonists

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