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Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism.
MedLine Citation:
PMID:  20714328     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective:To investigate the differential effects of acute central administration of distinct fatty acids (FA) on food intake, body weight and energy metabolism.Design:Male Sprague-Dawley rats were treated with bolus intracerebroventricular injections of control hydroxypropyl-β-cyclodextrin (HPB) or HPB complexed with 30 nmol of saturated palmitic acid (PA), monounsaturated oleic acid (OA) or polyunsaturated ω-3 docosahexaenoic acid (DHA). Food intake, body weight, neuropeptide expression and various serum parameters were assessed.Results:When compared with controls, rats injected with either OA or DHA had significantly reduced food intake and body weight for 48 h following injections. No significant changes in food intake or body weight were observed in the PA group. In conjunction with reduced food intake, hypothalamic anorexigenic pro-opiomelanocortin (POMC) gene expression was significantly augmented in the OA and DHA groups, with essentially no changes observed in the PA group. Changes in serum measures of energy metabolism also changed coinciding with the observed differences in food intake. Moreover, central administration of SHU9119, a melanocortin-4-rececptor (MC4R) antagonist, completely abolished the anorexigenic actions of OA, suggesting a role for OA-induced augmentation of hypothalamic POMC expression in mediating its central inhibition of food intake.Conclusions:The hypothalamus differentially senses FA and, specifically, that OA and DHA, but not PA, reduce food intake and body weight, which may be mediated through POMC/MC4R signaling.
Authors:
D R Schwinkendorf; N G Tsatsos; B A Gosnell; D G Mashek
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Publication Detail:
Type:  Journal Article     Date:  2010-08-17
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  35     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  336-44     Citation Subset:  IM    
Affiliation:
Department of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA.
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