| Effects of castration on insulin levels and glucose tolerance in the mouse differ from those in man. | |
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MedLine Citation:
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PMID: 20564323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plasma insulin concentration is increased in prostate cancer patients during androgen deprivation therapy (ADT) and hyperinsulinemia has been associated with aggressive prostate cancer behavior. To investigate the possible role of castration-induced hyperinsulinemia as a mechanism that may attenuate the beneficial effects of ADT in patients with prostate cancer, a murine model would be useful. We therefore investigated long-term metabolic effects of castration in several mouse models. METHODS: We studied the long-term influence of castration on energy intake, body weight, glucose tolerance, plasma-insulin, plasma insulin-like growth factor-1 (IGF-1), plasma adiponectin, and plasma leptin in C57BL/6, Swiss nu/nu, and CB17 scid mice receiving various diets. In each case, mice were randomized to have either bilateral orchiectomy or a sham operation. RESULTS: Energy intake, body weight, blood glucose levels in glucose tolerance test, plasma insulin, plasma IGF-1, and plasma leptin level in all had a trend to be decreased in castrated as compared to sham operated mice. Plasma adiponectin level was increased in the castrated mice. CONCLUSIONS: The effects of castration on glucose, insulin, and related markers in several mouse models studied does not coincide with clinical observations; further studies in this area will require clinical research and/or the use of alternate models such as the dog. |
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Authors:
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Takamitsu Inoue; Mahvash Zakikhani; Stéphanie David; Carolyn Algire; Marie-José Blouin; Michael Pollak |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Prostate Volume: 70 ISSN: 1097-0045 ISO Abbreviation: Prostate Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8101368 Medline TA: Prostate Country: United States |
Other Details:
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Languages: eng Pagination: 1628-35 Citation Subset: IM |
Affiliation:
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Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Androgens / deficiency* Animals Blood Glucose / metabolism* Body Weight / physiology Disease Models, Animal Energy Intake / physiology Glucose Tolerance Test Humans Insulin / blood* Insulin-Like Growth Factor I / metabolism Leptin / blood Male Mice Mice, Inbred C57BL Mice, Nude Mice, SCID Neoplasms, Hormone-Dependent / blood*, drug therapy Orchiectomy Prostatic Neoplasms / blood*, drug therapy Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Androgens; 0/Blood Glucose; 0/Leptin; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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