| Effects of castration on female rabbit bladder physiology and morphology. | |
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MedLine Citation:
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PMID: 15533516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the effect of ovariectomy on bladder blood flow and oxygen tension. Women are subject to bladder dysfunctions that occur less frequently in men. These include interstitial cystitis (syndrome of urgency, frequency, and pain on distension), incontinence, and bladder infections. It is believed that alterations in female sex hormones play a major role in mediating these abnormalities. We believe that alterations in estrogen can have marked effects on the blood flow to the bladder. METHODS: We divided 20 female rabbits into two equal groups: ovariectomized and sham operated. Six weeks later, the bladder of each rabbit was evaluated for bladder capacity, compliance, permeability, blood flow, tissue hypoxia, morphology, and smooth muscle contraction. RESULTS: Ovariectomy resulted in decreased bladder compliance; decreased blood flow to the bladder mucosa and uterus, a smaller decrease in blood flow to the bladder smooth muscle, and mucosal hypoxia; and statistically significant thinning of the bladder mucosa and increased mucosal permeability. CONCLUSIONS: Ovariectomy resulted in decreased blood flow and hypoxia to the bladder mucosa and a mildly decreased blood flow to the smooth muscle. The decreased blood flow and hypoxia may be related to the age-related uropathologic findings in postmenopausal women. |
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Authors:
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Mitesh H Parekh; Paul Chichester; Robert W Lobel; Ken Aikawa; Robert M Levin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Urology Volume: 64 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-09 Completed Date: 2005-11-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 1048-51 Citation Subset: IM |
Affiliation:
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Department of Uro-Gynecology, Albany Medical College, Albany, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Cell Hypoxia Female Mucous Membrane / blood supply, physiopathology Ovariectomy / adverse effects* Rabbits Urinary Bladder / blood supply*, physiopathology Urinary Bladder Diseases / etiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK 06114/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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