Document Detail


Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure: the PROTECT multicenter randomized controlled study.
MedLine Citation:
PMID:  18812677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Carperitide is used to treat acute decompensated heart failure (ADHF), but its effects on long-term prognosis have not been studied. METHODS AND RESULTS: A multicenter randomized controlled study of 49 patients with ADHF was performed to clarify the drug's effects on long-term prognosis. Low-dose carperitide (0.01-0.05 microg x kg(-1 ) x min(-1)) was infused for 72 h as the initial treatment (n=26), whereas in the control group (n=23), standard medical treatment other than carperitide was given without limitation. Anti-aldosterone drugs were prohibited in both groups. During carperitide infusion, significant increases of the atrial natriuretic peptide and cyclic GMP levels and a significant decrease in the heart-type fatty acid-binding protein/serum creatinine ratio were observed, suggesting inhibition of myocyte cell membrane damage. On the other hand, no significant differences in the plasma brain natriuretic peptide, troponin T, and creatinine levels were noted in either group. During 18-month follow-up, significant reductions of death and rehospitalization occurred in the carperitide vs control group (11.5% vs 34.8%; p=0.0359). Cox regression analysis revealed that randomization to carperitide (p=0.020), pretreatment systolic blood pressure >or=140 mmHg (p=0.043), and beta-blocker therapy (p=0.016) were independent predictors for freedom from cardiac events. CONCLUSIONS: Acute-phase low-dose carperitide infusion improved the long-term prognosis of patients with ADHF.
Authors:
Noritake Hata; Yoshihiko Seino; Takayoshi Tsutamoto; Shinya Hiramitsu; Noboru Kaneko; Tsutomu Yoshikawa; Hiroyuki Yokoyama; Keiji Tanaka; Kyoichi Mizuno; Jun Nejima; Masahiko Kinoshita
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-09-24
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-24     Completed Date:  2008-12-30     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1787-93     Citation Subset:  IM    
Affiliation:
Department of Intensive Care Unit, Chiba-Hokusoh Hospital, Nippon Medical School, Inba-gun, Chiba, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrial Natriuretic Factor / administration & dosage*,  blood
Blood Pressure / drug effects
Chronic Disease
Creatinine / blood
Cyclic GMP / blood
Fatty Acid-Binding Proteins / blood
Female
Follow-Up Studies
Heart Failure / blood,  drug therapy*
Humans
Male
Middle Aged
Natriuretic Peptide, Brain / blood
Prognosis
Remission Induction
Troponin T / blood
Chemical
Reg. No./Substance:
0/Fatty Acid-Binding Proteins; 0/NPPA protein, human; 0/Troponin T; 114471-18-0/Natriuretic Peptide, Brain; 60-27-5/Creatinine; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor

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