| Effects of carnitine and its derivatives on gastric acid secretion in rats. | |
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MedLine Citation:
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PMID: 9076846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carnitine is a natural substance that acts as a carrier of fatty-acids across the inner mitochondrial membrane for subsequent beta-oxidation. Acetyl-L-carnitine is the acetyl derivative of L-carnitine that has been shown to possess a slight cholinomimetic activity. Its success in sports medicine is dependent on the fact that it is able to stimulate the central nervous system functions. This study aims to investigate the effects of L-carnitine (LC) and its derivatives-acetyl-L-carnitine (ALC) and propionyl-L-carnitine (PLC)-on gastric acid secretion in rats. A concentration-dependent relationship with both ALC or PLC was observed in experiments in vitro using a rat isolated stomach. The addition of atropine to the perfusion bath only partially antagonized the effects of the two compounds. Stimulation of gastric acid secretion in a dose-dependent manner was also found when the tested compounds were administered i.v. to anaesthetized rats. To elucidate the mechanism of the gastric secretory response, assay for acetylcholine esterase activity using acetylthiocholine as substrate, was performed. It was found that ALC and PLC inhibited acetylcholine esterase, however, the IC50 for both compounds was about four times of magnitude greater than that of eserine. As the increase of the gastric acid secretion promoted by carnitines was blocked only partially by atropine both in vitro and in vivo, whilst it was completely abolished by experimental degeneration of the sympathetic neurons or by blockade of the postsynaptic sympathetic receptors, it is suggested that the effect of carnitines is determined by cholinergic and partly by adrenergic mechanisms. |
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Authors:
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M Valoti; A Benocci; K Marazova; P Mantovani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 34 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 1996 Nov-Dec |
Date Detail:
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Created Date: 1997-06-16 Completed Date: 1997-06-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 219-24 Citation Subset: IM |
Affiliation:
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Institute of Pharmacological Sciences, School of Pharmacy, University of Siena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcarnitine
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pharmacology* Animals Atropine / pharmacology Carnitine / analogs & derivatives*, pharmacology* Gastric Acid / secretion* Male Parasympathetic Nervous System / drug effects Rats Rats, Wistar Sympathetic Nervous System / drug effects |
| Chemical | |
Reg. No./Substance:
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14992-62-2/Acetylcarnitine; 17298-37-2/propionylcarnitine; 51-55-8/Atropine; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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